Sport-related concussions (SRCs) represent a major public health concern, accounting for more than 200,000 annual Emergency Department visits in the United States. Biomechanically, SRCs arise from head impacts that generate high-magnitude linear and rotational accelerations. Increasing evidence from human studies indicates that repetitive head impact exposure (HIE) reduces concussion tolerance...
Genome-wide association studies (GWAS) for biomarkers and molecular phenotypes can lead to clinically relevant discoveries. Numerous lines of evidence from both model organisms and human studies suggest that genetic associations can be highly heterogeneous, dynamic and context dependent. Despite twenty years of GWAS, most studies are based on statistical models that fail to account for such...
Protein degradation is a regulated process that reshapes the proteome and generates bioactive peptides. Peptidomics and degradomics enables large-scale measurement of these peptides, yet most
data analyses approaches treat peptides as isolated endpoints rather than intermediates produced
by sequential cleavage. Here, we introduce degradation graphs, a probabilistic framework that represents...
Bottom-up mass spectrometry-based proteomics studies changes in protein abundance and structure across various biological conditions. Since the currency of these experiments are peptides, i.e. subsets of protein sequences that carry the quantitative information, conclusions at a different level, e.g., at the level of proteins or of post-translational modifications, must be computationally...
