Growing concerns about the reproducibility, generalisability and (more recently) credibility of biomedical research publications underscore the need for methods that both synthesise evidence and diagnose weaknesses in the research ecosystem. Systematic review and meta-analysis of animal studies is traditionally used to evaluate preclinical efficacy and inform future research in animals or...
Preclinical studies tend to suffer from an unacceptably low rate of replicability, which is highly problematic since unreliable results from animal trials cannot provide a sound foundation for subsequent clinical research. Numerous factors contribute to this issue, including the misapplication of statistical methods, poor study design, and inadequate reporting of results. Although specific...
The reproducibility of research results is a cornerstone of trustworthy science. However, failures to reproduce published findings remain widespread across many disciplines. The way in which data analysis and statistics is taught to students often translates into how they later perform research in labs and clinics. Therefore, improving the reproducibility of biomedical research requires not...
