Early clinical trials play a critical role in drug development. The main purpose of early trials is to determine whether a novel treatment demonstrates sufficient safety and efficacy signals to warrant further investment (Lee & Liu, 2008). The new open source R package phase1b is a flexible toolkit that calculates many properties to this end, especially in the oncology therapeutic area. The...
Bayesian Methods in Registered Clinical Trials: A Systematic Review of Studies on ClinicalTrials.gov Through 2024
Giles Partington & Christina Geyer: Phastar
Bayesian methods are increasingly being incorporated into clinical trial designs to improve flexibility, efficiency, and interpretability. Earlier reviews of published studies (Lee & Chu, 2012) illustrated how these approaches were...
The Bayesian Logistic Regression Model (BLRM) with Escalation With Overdose Control (EWOC) is widely used in Phase I Oncology trials. Recently, several publications have highlighted a recurring issue: escalation can be blocked even when observed data strongly suggest safety. I.e., the posterior overdose probability at the next dose remains above the EWOC threshold despite no dose-limiting...
Effective air quality regulation and climate change mitigation depend on reducing greenhouse gas emissions and air pollutants. To achieve sustainable green development, this study constructs a spatio-temporal hierarchical model to assess the Air Quality Index (AQI) across Nigerian states and to derive actionable insights for environmental sustainability. Specifically, this study develops a...
