"Biotechnology engineering in a microgravity environment receives much attention these days. The absence of sedimentation enables scientists to combine any number of substances in an even mixture, prevent cell sedimentation, and enhance agglomeration into a natural 3D formation. Additional beneficial is the absence of hydrostatic pressure, permitting secondary forces like diffusion and surface tension to dominate. Missing tangential stress by the weight of the fluid to surfaces is eliminated as well, resulting in a significant reduction of shear forces which makes many experiments possible in space but only partly simulated on earth. A Random Position Machine (RPM) can simulate microgravity by a defined motion pattern so that the gravitational pull on the samples distributes equally, spatially, and temporally. In such a situation, the gravity vector averages mathematically to zero
Those unique in vivo like conditions lead to a new strategy for tissue engineering of multicellular cancer spheroids, organoids, artificial vessel constructs, and a variety of tissues for new opportunities for drug screening and biomarker discovery.
Yuri is a German space company founded in 2019 with our focus lying at the intersection between Aerospace Engineering and Life Sciences. Our goal is to democratize microgravity for life science research. With our teams summing up 30+ years of experience and 11 successful ISS payloads to date, we are helping our customers such as space agencies (e.g. NASA), research institutes (e.g. UCLA, Charité Berlin), and pharma giants (GlaxoSmithKline) to send their research to space easier, quicker and at a better price. With our reusable, flight-proven hardware, we are lowering the prices and times needed to get science into microgravity e.g., on suborbital flights or the ISS. Our portfolio also contains the two most used ground-based microgravity simulators, a 2D clinostat and the Random Positioning Machine (RPM), making us a true one-stop-shop for microgravity research. With our first own science launching this year to the ISS, we are in the process of extending our service and becoming the first life science-space company."