"Smart-materials based dynamically activated microenvironments for tissue engineering
C. Ribeiroa,b, S. Ribeiroa, M. M. Fernandesa,b, N. Castroc, V. Correiaa,d, U. Silvanc,e, and
aCentro de Física, Universidade do Minho, 4710-057, Braga, Portugal
bCenter of Biological Engineering, University of Minho, Braga 4710-057 Portugal
cBCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain
dCentro ALGORITMI , University of Minho, 4800-058 Guimarães, Portugal
eIKERBASQUE, Basque Foundation for Science, 48013 Bilbao, Spain.
Smart and multifunctional materials are increasingly being used in tissue engineering and regenerative medicine in order to dynamically provide specific clues to the cells. In particular, the use of magneto- and electroactive polymers that deliver electrical signals to the cells upon magnetic or mechanical solicitation, respectively, open new scientific and technological opportunities, allowing the development of suitable biomimetic microenvironments for tissue regeneration. In fact, electrical and electromechanical clues are among the most relevant ones in determining tissue functionality in tissues such as muscle and bone, among others, indicating their requirement for proper tissue regeneration.
This talk reports on the electroactive and magnetoelectric materials used for tissue engineering applications. The most used materials and morphologies are reported, together with novel bioreactor designs allowing to take full advantage of those materials. The main achievements, challenges and future needs will be presented and discussed.
This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2019, UID/BIA/04050/2013, UID/BIO/04469 and projects PTDC/BTM-MAT/28237/2017 and PTDC/EMD-EMD/28159/2017. The authors acknowledge funding by the Spanish State Research Agency (AEI) and the European Regional Development Fund (ERFD) through the project PID2019-106099RB-C43/AEI/10.13039/501100011033 and from the Basque Government Industry Department under the ELKARTEK program, respectively."