Fabrication of poly(HEMA-co-MMA) scaffold having surface roughness and modulus for soft-tissue engineering

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ICE Krakow

ICE Krakow

ul. Marii Konopnickiej 17 30-302 Kraków


Kim, Ja-rok (TE Bios)


"*Purpose/Objectives: The surface roughness, morphology and modulus of the scaffold are critical factors in tissue engineering and biomedical applications. In this study, we developed a scaffold suitable for the soft tissue with high modulus and surface modifications for excellent cell-adhesion and cell spreading by the poly(HEMA-co-MMA) concentration-responsive characteristics.

*Methodology: Porous scaffold for suitable roughness and mechanical property was fabricated by the polymerization of various ratio of HEMA and MMA. The mechanical characteristics include the surface roughness, modulus, pore size and cell toxicity, adhesion and proliferation activity depend on the ratio of HEMA and MMA were evaluated.

*Results: The surface morphology and the pore size of the scaffold were controlled by changing the ratio of HEMA and MMA. in particular, poly(HEMA-co-MMA) scaffold with 1-5 KPa which applicable to soft-tissue engineering were developed by the HEMA 90mol%, MMA 10mol% of total polymer content. The results of in vitro cell response assay showed the difference in cell adhesion and spreading on the scaffolds according to surface roughness and mechanical properties.

*Conclusion/Significance: In this study, the porous scaffolds made of poly(HEMA-co-MMA) exhibit surface roughness and mechanical properties suitable for soft tissue regeneration and tissue engineering."

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