Silver-doped calcium titanate layer with in vivo bone-bonding ability to fight bone bacterial infection in titanium implants

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ICE Krakow

ICE Krakow

ul. Marii Konopnickiej 17 30-302 Kraków


Piñera Avellaneda, David (Universitat Politècnica de Catalunya )


The rapid integration in the bone tissue and the prevention of bacterial infection are key for the success of the implant. In this regard, a silver (Ag) doped thermochemical treatment that generates an Ag-doped calcium titanate layer on titanium (Ti) surface was previously developed by our group in order to improve the bone-bonding ability and provide antibacterial activity 1. However, a greater biological characterization of the proposed material was mandatory. While the incorporation of silver imparts antibacterial properties to the material, this ion can have cytotoxic effects in eukaryotic cells. Thus, the objective of this work is to assess the biological effects of Ag+ in the calcium titanate layer, both in vivo and in vitro.

First, cell response in terms of cell adhesion, morphology, proliferation, and differentiation was evaluated using osteoblast-like cells (SaOS-2). Second, the proposed treatment was applied to commercial porous Ti implants (Osteosinter) to study osteointegration in vivo.

The incorporation of Ag is able to inhibit bacterial adhesion without showing any remarkable decrease of viability in osteoblastic cells. Moreover, Ag-doped calcium titanate displays strong bone-bonding ability by promoting extracellular matrix production in vitro. Regarding in vivo results, Ag-doping does not interfere in the outstanding bone-bonding ability of Osteosinter.

According to the results, the Ag-doped calcium titanate layer is an excellent strategy to prevent bone bacterial infection related to implants, which is also able to promote osteointegration.

  1. Rodríguez-Contreras, A. et al. Surf. Coatings Technol. 421, 127476 (2021)


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