Bioengineering vascularized microtissues

Jun 30, 2022, 11:00 AM
Room: S3 A

Room: S3 A


Barrias, Cristina (i3S/INEB-Instituto de Investigação e Inovação em Saúde/Instituto de Engenharia Biomédica)


Modular tissue-engineering approaches provide a promising strategy for building complex living structures from the bottom-up, through the co-assembly of microscale tissue units. Using biofabrication tools, multiple modular units of parenchymal, stromal, and vascular tissues can be rationally combined to recreate structurally/functionally different compartments of human organs. Microtissue units present a high surface area, which facilitates the diffusion/mobility of oxygen, molecules, and cells through interstitial gaps, affording a useful tool to generate densely cellularized 3D constructs. In this talk, we outline different approaches to engineering vascularized microtissues and describe some of their applications in the fields of regenerative medicine and in vitro modeling.


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