In vitro modeling of human brain region interactions

Jun 28, 2022, 3:50 PM
Room: S4 A

Room: S4 A


Reumann, Daniel (Institute of Molecular Biotechnology Austria (IMBA))


The human brain is unique in size and complexity, but also the source of some of the most devastating human diseases. While many of these disorders have been successfully studied in model organisms, recent experiments have emphasized unique features that can not easily be modeled in animals. We use cerebral organoids to recapitulate those features in vitro and to test their role in human disease.
While the human brain is subdivided into distinct functional areas along its rostro-caudal and dorso-ventral polarity axes, brain organoids are currently limited by the lack of such polarity. To overcome those problems, we have used two approaches. First, we have introduced localized engineered sources of morphogens that can induce polarity in elongated organoids. Second, we have fused organoids resembling distinct brain areas to recreate polarity axes. We will present approaches to recreate functionally integrated multi-part organoid systems and their application to model neuro-developmental and neurodegenerative brain disorders.


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