Inflammation – a Core Feature of Tendinopathies

Jun 30, 2022, 1:50 PM
20m
Room: S4 B

Room: S4 B

Speaker

Traweger, Andreas (Paracelsus Medical University)

Description

"Tendon disorders and injuries are one of the most common musculoskeletal disorders. Our knowledge of the causes and underlying mechanisms for the development of tendinopathies still remain fragmentary. Recent evidence has clearly implicated the presence of immune cells during early tendinopathy and we are beginning to better understand the origin and properties of these cells. Recently, we described tissue-resident cells fulfilling macrophage- or monocyte-related functions in healthy tendons, most likely serving as sentinels which are activated upon tendon tissue injury or pathological stress.
Various intrinsic and extrinsic risk factors have been identified and next to mechanical overuse, other known predisposing factors include rheumatoid arthritis, diabetes, obesity or smoking, all of which elicit or are accompanied by a mild systemic inflammation. We could show that not only local inflammation can affect tendon quality, but the mere presence of a low-grade, allergy-induced systemic inflammation is sufficient to induce structural alterations in tendons and impair tissue function.
In this presentation I will give an overview on the recent advancements in defining the key role of immune-mediated mechanisms in tendon disease."

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