"Many biomaterials have been proposed to produce porous scaffolds, nanofibers and nanoparticles for different medical treatments and applications. Systems combining natural polymers and synthetic biodegradable polymers offer particular properties adequate for those demanding applications. Those biomaterial systems can be tailored with enhanced mechanical properties, processability, cell-friendly surfaces and tunable biodegradability. Those biomaterials can beprocessed by melting or solvent routes into devices with wide range of applications such as biodegradable scaffolds, films or particles and adaptable to many other high performance biomedical applications.
Non-woven meshes of polymeric ultrafine fibers with fiber diameters in the nanometer range can be produced by electrospinning. Those meshes are highly porous and have a high surface area-to-volume ratio. Furthermore, they can mimic the fibrous structure of the extracellular matrix of human tissues and can be used as scaffolds for Tissue Engineering (TE). There is a great interest in developing also nanoparticles and hydrogels from those polymeric systems for injectable treatment modalities. All those structures can be used as substrates for specific surface functionalization having fine-tuned bioactivity and biological performance. This strategy enables developing highly controlled devices for exposure, capture and, whenever needed, inactivation of biological biomolecules. Those high-performance devices offer the specificity and local bioactivity that enable to design novel treatment modalities in various disease conditions.
This talk will review our latest developments biomaterials, nanoparticles and nanofibre meshes in the context of novel therapeutic applications."