Conveners
S10-1 Biofabricated Tissues and Organs for Clinical Impact
- Andrew Daly (Biomedical Engineering, and CรRAM, at the National University of Ireland, Galway, Ireland)
- Laura De Laporte
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Malda, Jos (UMC Utrecht)6/29/22, 11:00โฏAMinvited lecture
Three-dimensional (3D) printing is already routinely used in the clinic, e.g. for pre-operative models or intra-operative guides. However, this does not involve the generation of living 3D structures, i.e., biofabrication of tissues and organs. This automated approach holds potential to advance the field of regenerative medicine as outer shapes can be personalised and organised constructs can...
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Falcones, Bryan (Lung Biology, Lund University )6/29/22, 11:20โฏAMpodium presentation
Introduction: Mesenchymal stromal cells (MSC)-based therapies for inflammatory diseases rely mainly on the paracrine ability to modulate different cell populations involved in the advance of the disease, such as macrophages. These immune cells possess a broad spectrum of inflammatory responses. In addition, previous data have shown that the MSC secretome influences macrophage phenotype and...
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Garcia Garcia, Alejandro (Laboratory for Cell, Tissue and Organ engineering. Wallenberg Centre for Molecular Medicina. Lund University )6/29/22, 11:30โฏAMpodium presentation
Introduction: Recent bone tissue engineering strategies propose recapitulating the endochondral ossification process for an effective repair. To this end, primary human mesenchymal stromal cells (hMSCs) can be primed in vitro towards hypertrophic cartilage (HyC) formation. While holding promises, limits arise from the performance variability associated with the use of primary cells. Recently,...
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L'Heureux, Nicolas (Univ. of Bordeaux, Inserm, Lab. for the Bioengineering of Tissues (BioTis UMR 1026) )6/29/22, 11:40โฏAMpodium presentation
Since synthetic vascular prosthesis perform poorly in small diameter revascularization, biological vascular substitutes are being developed as an alternative. Although their in vivo results are promising, their productions involve tissue engineering methods that are long, complex and expensive. To overcome these limitations, we propose an innovative approach that combines the human amniotic...
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Guillet, Manon (Universitรฉ de technologie de Compiรจgne )6/29/22, 11:50โฏAMpodium presentation
Introduction
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To overcome organ shortage, designers develop engineered livers: devices/methods aiming to temporally assist or permanently replace it. As a complex organ with more than 500 functions, the design of engineered livers is one of the greatest challenges of the field. Since the mid-20th century, multiple pathways have been taken using diverse materials such as charcoal or cells. We... -
Lode, Anja (Centre for Translational Bone, Joint and Soft Tissue Research, Technische Universitรคt Dresden )6/29/22, 12:00โฏPMpodium presentation
Introduction
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In vitro liver models allow investigation of the cell behavior in disease conditions or in response to changes in the microenvironment and are therefore valuable tools for basic research, drug screenings or toxicological analyses. Mimicking the tissue-level complexity of liver to achieve functional constructs is a major challenge, however, 3D bioprinting technologies open novel... -
Campinoti, Sara (Roger Williams Institute of Hepatology )6/29/22, 12:10โฏPMpodium presentation
Introduction: Mortality caused by liver disease and its complications is on the rise, representing a significant global health issue. Transplantation is the only efficient treatment for end-stage liver disease but is limited by the shortage of organ donors. Bioengineering represents a promising option, with researchers aiming at developing suitable organ replacements for transplantation....
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Gasperini, Luca (3B's )6/29/22, 12:20โฏPMpodium presentation
Introduction: Dynamic culturing systems can overcome challenges of in-vitro fabrication and maintenance of complex 3D tissues, however, the unique physiological conditions to which each tissue is subjected has been hampering noteworthy developments for many engineered tissues. Here we report the in-house development (design, manufacturing, and validation) of a glass slide size microbioreactor...
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Golafshan, Nasim (Department of Orthopaedics, University Medical Center Utrecht, Utrecht University, GA Utrecht, The Netherlands )podium presentation
The interface between bones and connective tissues, i.e. cartilage, ligament and tendon, is characterized by changes in cell phenotype and matrix composition and organization. These changes result in graded mechanical properties that allow the transmission of load without creating stress concentrations. In some interface regions, differences in mechanical properties, such as stiffness, can...
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