Conveners
S23+S31+S32 Can we bioengineer tissues using artificial cells? + Extracellular vesicles – next generation tool for diagnostics and regenerative medicine + Extracellular vesicles for soft tissue repair
- Catherine Le Visage (Nantes Université, Oniris, Univ Angers, CHU Nantes, INSERM, Regenerative Medicine and Skeleton, RMeS, UMR 1229)
- Paula Vena
- Ewa Zuba-Surma (Jagiellonian University)
- Barbara Łukomska (NeuroRepair Department, Mossakowski Medical Research Institute, Polish Academy of Sciences)
- Anne Des Rieux
Artificial cells have been topic of intensive investigation over the past years. Although in first instance they have been mainly developed as a platform to attain a better fundamental understanding how living cells operate, they have recently also been recognized as interesting structures in biomedical research. In this lecture I will discuss an artificial cell system based on complex...
Artificial cells are biomimetic systems used to study properties of biological cells and to explore new possible applications in place of biological cells. Tissue engineering aims at replacing or recovering damaged or diseased tissues, or reconstituting tissues in vitro for disease modelling and drug development. Artificial cells can be combined with modern biofabrication strategies like...
"Tendon injuries are the top reported musculoskeletal injuries with Achilles, patellar, and rotator cuff tendons as the most common types of tendon injuryy (Ackermann & Institutet, 2013). Tendon injuries are a common cause of disability and account for decreased productivity. Both chronic and acute injuries can result in long-term pain and disability(Pabón & Naqvi, 2021).Extracellular...
MATRIX-BOUND NANOVESICLES AS SELECTIVE MODULATORS OF THE IMMUNE RESPONSE
Introduction: Matrix bound nanovesicles (MBV) have recently been identified as an inherent component of the extracellular matrix (ECM) and possess the ability to mitigate the proinflammatory activation state of macrophages. While the “anti-inflammatory” properties of MBV have several potential clinical applications, it...
Purpose/Objectives: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation and destruction of synovial joints that affects approximately 7.5 million people worldwide. Disease pathology, while multifactorial in etiology, is driven by an imbalance in the ratio of pro-inflammatory vs. anti-inflammatory immune cells, especially macrophages. Modulation of...
Introduction. Matrix-bound nanovesicles (MBV) are nanometer-scale extracellular vesicles secreted by cells and found embedded within the extracellular matrix (ECM)[1]. MBV are similar to exosomes in size and shape, but MBV have distinctly different lipid profiles and RNA cargo[2]. MBV have demonstrated the ability to induce an M2-like pro-healing macrophage phenotype, promote neuronal stem...
"PLATELET-DERIVED EXTRACELLULAR VESICLES SHOW THERAPEUTIC EFFECTS ON A 3D TENDON DISEASE MODEL
Ana Luísa Graça1,2, Rui M. A. Domingues1,2, Isabel Calejo1,2, Manuel Gómez-Florit1,2 and Manuela E. Gomes1,2
13B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue...
