Conveners
S24 Cell-rich constructs for tissue engineering
- Manuel Salmeron-Sanchez
- Christina Schofield (Centre for the Cellular Microenvironment, University of Glasgow)
- Elana Meijer (UMC Utrecht, department of Nephrology and hypertension)
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Mano, Joรฃo (University of Aveiro)6/29/22, 1:30โฏPMinvited lecture
Bioinspired engineered microenvironments provide cells with a holistic โinstructive nicheโ that offers the adequate entourage for cellular control both in space and time. Biomaterials provides essentially surface signals. We hypothesise that volume characteristics of biomaterials have a negligible influence on cell-behaviour and new tissue formation as compared with interfacial mechanical,...
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Muller, Laurent (CIRB-Collรจge de France )6/29/22, 1:50โฏPMpodium presentation
Vasculature plays an essential role in skin physiology and its architecture and function are altered in aged and diseased skin. Quite remarkably, papillary and reticular dermis show very distinct extracellular matrix (ECM) and vascularization. Furthermore, fibroblasts freshly isolated from their native microenvironment have different gene expression patterns, morphology and proliferation rate....
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206. AN IN VITRO IMMUNOCOMPETENT HUMAN TISSUE-ENGINEERED MODEL OF ATOPIC DERMATITIS FOR DRUG TESTINGBarragan Vazquez, Inmaculada (School of Clinical Dentistry, University of Sheffield )6/29/22, 2:00โฏPMpodium presentation
Introduction: Atopic dermatitis (AD) is a chronic inflammatory and common skin disorder that is frequently associated with other atopic diseases such as allergic rhinitis and asthma. The immunopathogenesis of AD is a complex process, as both innate and adaptive immune systems are involved in the development of eczema in those patients. Keratinocytes, mast cells, dendritic cells, and T cells,...
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Chaaban, Mansoor (University of Basel )6/29/22, 2:10โฏPMpodium presentation
Introduction:
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Stromal vascular fraction (SVF) cells, isolated from adipose tissue are an abundant easily accessible stromal cell source for bone tissue engineering. These characteristics make them a good alternative to bone marrow derived mesenchymal stem cells (BM-MSCs). Previous studies from our group provided a proof-of-concept that Adipose-derived Stromal Cells (ASCs), resulting from the... -
Zargarzadeh, Mehrzad (CICECO, University of Aveiro )6/29/22, 2:20โฏPMpodium presentation
Our newly developed self-feeding hydrogels with enzyme-empowered degradation capacity have demonstrated high biological performance in-vitro and in-vivo as a novel self-maintained and biocompatible 3D scaffold1. Photo-crosslinkable platelet lysates (PL)-based hydrogels have exhibited to support distinct human-derived cell cultures owing to their high content of bioactive molecules, such as...
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De Graaf, Petra (UMC Utrecht, RMCU and Department of Urology )6/29/22, 2:30โฏPMpodium presentation
Background:
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Urethral reconstruction is performed in patients with urethral strictures or for correction of congenital disorders. In most instances, foreskin or buccal mucosa flaps are used in these surgeries. However, complications may occur due to limited availability of tissue. In the future, tissue engineering (TE) might offer alternative solutions as it enables a detailed design to... -
Beaumont, Ross (Royal Veterinary College )6/29/22, 2:40โฏPMpodium presentation
Introduction
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Tendon injuries are common in equine athletes. Tissue healing occurs via biomechanically inferior scar tissue deposition, often resulting in re-injury. This is mediated, in part, by excessive proinflammatory cytokine release in the acute stages following injury. Stimulating equine tenocytes with interleukin 1 beta (IL-1ฮฒ) alters tendon-associated and extracellular matrix... -
Cartaxo, Ana Luรญsa (Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior Tรฉcnico, Universidade de Lisboa, Lisbon, Portugal; Associate Laboratory i4HB - Institute for Health and Bioeconomy, Instituto Superior Tรฉcnico)6/29/22, 2:50โฏPMpodium presentation
Introduction: Fecal incontinence has a high impact on patient quality of life. Available treatments based on surgical and non-surgical approaches range from change in diet, to bowel training or sacral nerve stimulation, none of which represent a long-term solution. Novel therapies are emerging that aim to regenerate the sphincter muscle and, therefore, restore continence. These approaches...
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Fang, Ling (Department of Materials Science and Engineering in National Tsing-Hua University )podium presentation
Introduction
The subcutaneous space is an attractive alternative site for engineering vascular networks, since it provides relatively easy accessibility, minimal invasiveness, and potentially high transplant capacity. However, itโs also a poorly vascularized site that often fails to achieve the level of vascularization necessary to maintain function of thick grafts.1 Here, we patterned our...
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