Conveners
S34 Advanced therapy approaches in tissue engineering
- Irene Lara-Saez
- Wenxin Wang (University College Dublin)
- Hector Capella-Monsonis (McGowan Institute for Regenerative Medicine, University of Pittsburgh )
- Lisanne Laagland (Utrecht University)
Gene therapy is the most promising treatment for recessive dystrophic epidermolysis bullosa (RDEB), however genetic cargo delivery efficiency is still a technical limitation. Viruses are the traditional vector of preference for gene therapy, as virus trophism increase tissue specificity. However, drawbacks related with safety and high manufacturing costs have facilitated the expansion of...
"INTRODUCTION: There remains a substantial unmet clinical need for tissue engineered strategies to heal large volume bone defects. The delivery of microRNAs from biomaterial-based scaffolds presents a promising approach: whereby the scaffold provides a structural support to bone tissue while the microRNAs (miRs) induce the endogenous cells to produce relevant therapeutic proteins and genes at...
"Introduction:
Cystic fibrosis (CF) is a lethal autosomal recessive inherited disease caused by mutations in the CFTR gene encoding the CF transmembrane conductance regulator (CFTR) protein, and has no cure to date. CFTR gene mutations lead to abnormal chloride ion transport in epithelial tissues, which changes the hydration and pH of fluids and mucus, affecting respiratory (main cause of...
"Introduction: Osteoporosis (OP) is characterized by a loss in bone mass and mineral density1. The stimulation of the canonical Wnt/β-catenin pathway has been reported to promote bone formation by increasing the osteogenic potential of mesenchymal stem cells (MSC)2. This pathway is controlled by several regulators as secreted frizzled-related protein-1 (Sfrp-1) that acts as an antagonist3....
"Trauma is the leading global cause of mortality and disability. Patient management after trauma can be challenging, particularly in a multiple trauma setting, a condition characterized by several severe injuries. Multiple trauma can elicit major immunological responses, such as systemic inflammatory response syndrome, which lead to a deterioration in the patient’s condition. The complement...
Mesenchymal stem cells (MSCs) have been studied for the treatment of Osteoarthritis (OA), the most common chronic disease of joint cartilage. A potential mechanism of MSC-based therapies has been attributed to the paracrine secretion of trophic factors, where extracellular vesicles (EVs) may play a major role. It is suggested that MSCs from younger donor sources compete are optimal with...
"Human long-lived plasma cells (LLPCs) are terminally differentiated effector cells of the B-lymphocyte lineage that reside in specialized niches in the human bone marrow (BM) harboring many different microenvironmental niches. LLPCs play an essential role in the humoral immune protection by maintaining constant high-affinity antibody levels against pathogens and their toxic products,...
INTRODUCTION: Within the field of tissue engineering, biomaterial scaffolds augmented with gene therapeutics have emerged as a promising treatment strategy for tissue regeneration. To date, the majority of ‘gene-activated’ scaffolds in tissue engineering have utilised plasmid DNA as the gene therapeutic of choice. Recently, messenger RNA (mRNA) has emerged as an attractive alternative to...
"Intracellular delivery of advanced biological and supramolecular agents holds great potential for fundamental and translational biomedical research, but it is staggeringly complex due to the natural biological barriers that have evolved to protect the cell. A plethora of viral, chemical, and physical approaches have been developed to facilitate delivery of biomolecules into different cell...
