Conveners
S38 Injectable biomaterials for cell-instructive matrix cues
- Mirosława El Fray (West Pomeranian University of Technology, Szczecin )
"Introduction
Minimally invasive surgery for the restoration of bone tissues lost due to diseases and trauma is preferred to reduce patient complications and health care costs. The current challenge is to design material at the site of surgery with specific behaviors for mimicking the natural structures and delivering appropriate signals to cells promoting tissue repair/regeneration. ...
Glycosaminoglycans (GAGs) within extracellular matrices (ECM) control the presentation of soluble, cell-instructive signals. The incorporation of GAGs into engineered polymer networks can therefore provide a powerful and versatile means of directing cell fate. We have established a rational design strategy for ECM-inspired hydrogels based on multi-armed poly(ethylene glycol), GAGs of different...
"Introduction. One challenge of developing biomaterials for tissue engineering is the capability to precisely engineer desired properties, while keeping robustness and versatility in the system. Cell-encapsulating hydrogels are used as extracellular matrix mimics for basic study of cell function, high-throughput drug screening, and therapeutic delivery. In their molecular design, the...
"Introduction
Alginate is widely used in the biomedical field, particularly to build three-dimensional (3D) systems with ECM-like properties. Despite being a bio-inert biomaterial, alginate can be chemically modified to promote highly specific cell-ECM interactions[1]. We have shown that molecularly designed alginate 3D matrices recap key features of native ECMs supporting tissue...
"Injectable biomaterials for cell and drug delivery is a rapidly expanding field that may revolutionize medical therapies. Here we report on the fabrication of injectable electrospun microscaffolds used to deliver desired cargo through the needle. We observed an efficient attachment of cells to the scaffold's surface, creating cell-populated microscaffolds (MS) that could be injected or 3D...
The components of cellular microenvironments, especially the extracellular matrix (ECM), strongly regulate biological processes through biochemical and mechanical signaling. For this, hydrogels have been widely used to build artificial niches mimicking the native ECM. Strain-promoted azide-alkyne cycloaddition (SPAAC) is a biorthogonal reaction between strained cyclic ring-containing alkynes...
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Injectable biomaterials have evolved from serving as simple structural fillers to acting as multi-functional systems capable of directing human mesenchymal stromal cell (hMSCs) response. However, the selection of appropriate design parameters for injectable polymeric microbeads for translational applications remains a challenge. We have demonstrated promising strategies to address this need...
