Conveners
S39 Injectable composite hydrogels as scaffolds and drug delivery systems for tissue engineering
- Beata Niemczyk-Soczynska (Institute of Fundamental Technological Research, Polish Academy of Sciences)
- Paweł Sajkiewicz
Introduction:
Injectability is one of the most desirable features of biomaterials. The combination of injectability and photocuring can provide materials to be easily and safely delivered using minimally invasive procedures. This is especially important for tissue sealants which allow to exclude the use of sutures or staples or for patches supporting the weakened tissue. Therefore, the aim of...
"Introduction
The aim of this research was to design and obtain an injectable thermosensitive hydrogel consisting of methylcellulose (MC) and agarose which would serve as a smart scaffold for tissue engineering applications. The MC provides thermal sensitivity, while heated up to c.a. 37 ℃ becoming a physically crosslinked hydrogel. While agarose enhances crosslinking of MC rate and increases...
"Introduction:
Human Mesenchymal stromal cells (hMSC) are appealing candidates for regenerative medicine applications. However, upon implantation, they encounter an ischemic microenvironment depleted of oxygen and nutrients responsible for their massive death post-transplantation, a major roadblock to successful clinical therapies. To date, various approaches have been proposed to address...
"Introduction. Despite being the youngest branch of regenerative medicine, neural tissue engineering has rapidly developed, with numerous advances close to clinical translation. One of the most researched areas are tissue engineering and regenerative medicine approaches for brain repair after ischaemic stroke, with more than 70 preclinical studies testing therapeutic combinations of...
"Adhesive biomaterials have been studied by the scientific community in an attempt to surpass the current disadvantages of sutures and staples in surgery, such as the challenging implementation in some tissues and the risk of infection. The developed bioadhesives have been used as: i) glues for maintaining biological tissues together after laceration; ii) tissue sealants for preventing the...
"Introduction. Breast cancer is considered nowadays the most common cause of death for female population. Since traditional treatments (e.g., chemotherapy, radiotherapy, surgery) showed several drawbacks [1], Drug Delivery Systems (DDS) recently gained interest due to the possibility to release therapeutic agents locally and controllably in targeted sites. Herein, we aimed to develop stable...
Introduction
Neurodegenerative diseases (NDs) are a group of chronic disorders (e.g. Alzheimer’s disease, Parkinson’s disease and multiple sclerosis -MS) characterized by progressive neurological dysfunction. Despite different neuronal populations can be affected, NDs share major clinical manifestations, namely motor impairment, cognitive disability and/or dementia. Effective treatments do...
"INTRODUCTION
The regenerative effect of Platelet Rich Plasma on skin and other tissue lesions is well known. If, on the one hand, research aims to optimize PRP standardized protocols, on the other hand, it aims to identify substrates as vehicles for the platelet content release to the lesion site. For the latter purpose, hyaluronic acid (HA) is proposed thanks to its viscoelastic and...
Proper, consistent and correct biomechanical characterization is very important for 3D bioprinted scaffolds. Conventional approach foresees pre-selection of the material model and fitting experimental data to quantify properties in time and spatial scales. For injectable biomaterials the interaction of the biomaterial and the system as well as various dissipative phenomena (often uncontrolled)...
"Hydrogels are among the most desired biomaterials due to their ability to mimic the native extracellular matrix (ECM) of tissues, cytocompatibility, multifunctionality, tunable gelation, and resilient mechanical properties 1,2. Hydrogels hold the particularity of being responsive to different stimuli (e.g., stress, temperature, pH, and light), which makes them suitable to be applied the...
