Conveners
S41 Mesenchymal Stem / Stromal Cells - from basic research through clinical studies to registered products
- Maria Rita Citeroni (Unit of Basic and Applied Biosciences, Faculty of Bioscience and Agro-Food and Environmental Technologies, University of Teramo, Teramo, Italy )
- Ewa Zuba-Surma (Jagiellonian University)
- Marcin Majka
Mesenchymal stem/stromal cells (MSCs) are considered a disease-modifying treatment for osteoarthritis (OA). However, the precise molecular mechanisms of actions under which MSCs exert their therapeutic effect have not yet been identified in OA. Since MSCs actively interact with their environment, most likely the inflammatory OA milieu will stimulate their response. To identify these...
"EFFECT OF DIFFERENT LIGHT WAVELENGTHS ON ADIPOSE TISSUE-DERIVED MESENCHYMAL STEM/STROMAL CELLS
Introduction: Treatment of cells with electromagnetic irradiation (light) can affect their proliferation and differentiation ability. Exposure of cells to light sources with different wavelengths (wavelengths around 415 nm/blue, 540 nm/red, and 810 nm/infrared are most common) appears to have...
"Introduction
The wide spectrum of brain injuries experienced in neonates and preterm newborns and the potential plasticity of the CNS prompts us to seek solutions in the field of neuroregeneration in this group of patients and to prevent the worst effects of prematurity and perinatal problems. Drug-resistant epilepsy remains one of the biggest problems of prematurity and its consequences....
Cell-based therapies in the clinic are limited by the number of cells that can be produced quickly and inexpensively. Whereas about one million cells are isolated from a single donor, existing cell-based therapies can require hundreds of millions to billions of cells. Rapid, exponential expansion of cell number would allow faster delivery of life-saving treatments, such as bone marrow...
"<div>Endochondral bone regeneration (EBR) recapitulates natural development of long bones during embryogenesis and fracture repair through implantation of a cartilaginous template into a defect, which is eventually remodeled into bone. Typically, autologous multipotent mesenchymal stromal cells (MSCs) are exploited to generate such cartilage constructs. However, the use of patient-own cells...
"Introduction
Adipose-derived mesenchymal stem cells (hADMSCs) are a promising resource for regenerative medicine. They can be harvested directly from the patient with moderately invasive procedures and re-implanted without eliciting immune response. To date, several clinical trials are active in phase II-III, but new technologies are needed to make these therapies more efficient. In...
"Introduction
Acute kidney injury (AKI) is an independent risk factor for end-stage renal disease (ESRD) and death and is characterized by a sudden failure of renal function. The standard approach to treat AKI is mostly supportive in nature. Stem cell therapy is a promising approach in regenerative medicine and has shown to work through multiple mechanisms to effect tissue repair. Mesenchymal...
Derivation of Hepatocytes from stem cells have been established through various protocols including growth factors (GF) and small molecules (SM) among others. However, mesenchymal stem cell-based derivation of hepatocytes still remains expensive due to the use of cocktail of growth factors and also requires long duration for differentiation, thus limiting its potential clinical applications....
