Conveners
S50 One health, one medicine: What Veterinary regenerative medicine can teach us
- Debbie Guest (Royal Veterinary College)
- Michelle Teunissen (Faculty of Veterinary Medicine, Utrecht University)
- Iris Gerner (Vetmeduni Vienna)
"Introduction
We have derived horse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Pluripotent stem cells undergo unlimited self-renewal and can differentiate into every tissue of the body; properties which can be utilised for therapeutic applications and disease modelling.
We have investigated their application in tendon injuries and catastrophic bone fractures,...
"Background Synovial membrane-derived mesenchymal progenitor cells (SM-MPCs) are a promising candidate for the cell-based treatment of osteoarthritis (OA) considering their in vitro and in vivo capacity for cartilage repair. However, the OA environment may adversely impact their regenerative capacity. There are no studies for canine (c)SM-MPCs that compare normal to OA SM-MPCs, even though...
"Background Osteoarthritis (OA) is a common degenerative joint disease, that affects the whole joint. Knee joint distraction (KJD) has been proposed as an alternative joint-preserving treatment strategy for relative young patients with end stage OA. Although there is evidence for the clinical and structural benefits of KJD, the regenerative mechanisms behind KJD remain unclear. This study...
"Introduction:
Intervertebral disc (IVD) degeneration is among the leading cause of low back pain, disability and morbidity worldwide. As the world population ages and only symptomatic treatment exist, IVD regeneration is a major public health challenge for the upcoming years. Human IVD cells are difficult to obtain, especially healthy ones, and murine IVDs present numerous differences with...
"The phenotypic characterization of multipotent mesenchymal stromal cells (MSC) still suffers from deficits and the resulting heterogeneity of MSC used in different preclinical and clinical studies hamper the translational success. In search for novel MSC characterization approaches to complement the traditional trilineage differentiation and immunophenotyping assays reliably across species...
Introduction:
Immunomodulation and immunogenicity of mesenchymal stem cells (MSCs) may influence their efficacy and safety, thus being key for their therapeutic use. The immune regulatory mechanisms of MSCs depend mostly on the secretion of different mediators which are not only important for the MSC therapeutic mechanisms but also to facilitate their escape from immune recognition when...
"EVs in equine regenerative medicine – challenges and potential therapeutic implications.
Mesenchymal stem/stromal cell (MSC) derived EVs have shown an equivalent therapeutic potential to their donor cells, making them a promising tool for regenerative medicine. However, non-standardised EV isolation methods and the limited availability of cross-reacting markers for most animal species...
"Introduction
Tendon injuries in humans are a major healthcare concern but they also occur spontaneously in other species including horses. The superficial digital flexor tendon (SDFT) of the horse is a highly relevant model for studying tendinopathies because it is a functional homologue of the Achilles tendon with similarities in aetiopathogenesis and associated risk factors (1,2). Previous...
Introduction:
Most current animal vaccine regimes involve a primary vaccination followed sometime later by a booster vaccination. This presents challenges when vaccinating difficult to access animals such as livestock. Mustering livestock to deliver a vaccine boost is costly and stressful for animals. Thus, we have produced a platform system that can be administered at the same time as the...
