Conveners
S51+S29 Perspectives and Challenges in Bioengineering Dynamic Hydrogels for Regenerative Medicine + Engineered viscoelasticity in cell and tissue engineering
- João Mano (University of Aveiro)
- Jacek K. Wychowaniec (AO Research Institute Davos, Clavadelerstrasse 8, 7270, Davos, Switzerland )
- Aline F. Miller
3D culture and organoid technologies have been developing rapidly in the last decade, and already found widespread applications in biology and medicine. While cells, and stem cells in particular, have tremendous self-organization potential, most applications benefit from further engineering of the cellular microenvironment in order to guide the morphogenesis.
We will describe several...
Growth factor (GF) based therapies in regenerative medicine are limited by the high cost, fast degradation kinetics, and lack of specificity as consequence of the multiple functions of GF in the cell. One common GF therapeutic scenario is the administration of VEGF to support vascularization during tissue regeneration. The therapeutic window for VEGF treatment is narrow: low doses are safe but...
Introduction:
Recently, tissue engineering still lacks thorough vasculature, which represents a major drawback in developing physiologically relevant tissue constructs. Among others, the design and the biofabrication of blood vessels at the microscale remain challenging, due to their role in nutrient and oxygen exchange, but also waste removal. Parallelly, fiber-based biofabrication...
Myotendinous junction disfunctions due to degenerative musculoskeletal diseases or injuries resulting from strenuous physical activities are still considered an ongoing issue in the field of musculoskeletal tissue engineering. Indeed, the main challenge of biofabrication strategies relies on the development of methods enabling the generation of artificial bio-constructs that can replicate the...
"Introduction: Articular cartilage (AC) defects remain a significant clinical challenge[1]. This is partially due to the challenging nature of recapitulating the complex layered structure observed in the naturally curved AC tissue. While three-dimensional (3D) bioprinting appeared as a promising Tissue Engineering (TE) approach, it has serious limitations in the fabrication of curved...
"Introduction: Bioprinting is a booming and promising technology to create tissue models, with numerous applications in tissue engineering and regenerative medicine. However, the biomaterials commonly used for bioprinting involve non-physiological stimuli (e.g., sudden changes in temperature, pH, ionic forces) and lack tunability post-printing. These biomaterials are therefore still far from...
"Introduction
Short peptide amphiphiles have been widely reported as building blocks of supramolecular hydrogels for biomedical applications1,2, as they can copycat bioactive protein sequences. However, in the extracellular matrix (ECM), proteins are usually present as glycoproteins with different roles, e.g., storage depots of proteins and co-receptors. In this context, the use of...
