Conveners
S52 Perspectives For Future Innovation in Tendon repair (P4 FIT)
- Giovanna Della Porta
- Nicholas Forsyth
In this presentation the latest advances in the field of biomaterials for tendon repair will be presented. Current technologies put forward for engineering tendon tissue will be discussed. The focus of the presentation will be on the latest developments in electrospun based scaffolds exhibiting suitable time dependant mechanical properties, nanoscale (fibrous) topography and the ability to...
"Epithelial-to-mesenchymal transition (EMT) is a key event in embryo development and post-natal life in which epithelial cells undergo to a transdifferentiation into mesenchymal cells by acquiring a mobile state. This cell transitioning process recognizes the activation of signaling pathways which occur under controlled environments in response to factors controlling stem cell epigenetic...
The poor healing ability of tendons as well as the limitations of currently used therapies have motivated tissue engineering (TE) strategies to develop living tendon substitutes. At the same time, the significant lack of knowledge on tendon homeostasis and disease mechanism trigger our interest to focus on the development of adequate 3D tissue models that can provide important insights for...
"Introduction: MicroRNAs are short, non-coding RNA sequences with the ability to inhibit the expression of a target mRNA at the transcriptional level. MiRNAs are involved in the regulation and modulation of both regenerative and degenerative processes, playing crucial regulatory roles in tissue healing and regeneration. This particular feature makes this family of molecules a very interesting...
Tendon/ligament injuries are a relevant clinical problem in modern society. Although these tissues can selfheal when a lesion occurs, the complete functional recovery is difficult to achieve due to their low cellularity and vascularity. Moreover, reconstruction strategies have a non-negligible failure rate [1]. Failures often occur at the enthesis, the tendon/ligament-bone insertion [2]. This...
"Introduction: Tendinopathies are one of the most common musculoskeletal conditions. Unsatisfactory healing has a significant impact on the life of patients and imposes a remarkable socioeconomic burden. The recovery from tendon injuries is slow and requires extensive rehabilitation. The resulting scar tissue lacks the mechanical integrity of the original tissue, and therefore complete...
"Introduction: Tendons are dense connective tissues, necessary for the integrity and function of musculoskeletal system. Poor tendon repair remains a serious clinical problem, due to the difficulties in reorganising the complex multiscale hierarchical structure of native tendons. Tendon stem/progenitor cells (TSPCs) were recently identified as tendon-specific adult stem cells that exhibit...
