Conveners
S53 Prospects and Challenges in Biological Therapies for Tendon Regeneration
- Mohammad El Khatib (Unit of Basic and Applied Sciences, Faculty of Biosciences and Agro-Food and Environmental Technologies, University of Teramo)
- Manuela E. Gomes
- Denitsa Denitsa (University Wuerzbug, Department of Musculoskeletal Tissue Regeneration)
Impaired tendon function leads to pain and restricted movement of the joints. This impairment can be due to the degeneration of the tendon and, in the worst-case, due to rupture. Conservative and surgical treatments are available, however treatment duration can be long and the failure rate is high. In order to develop new treatment strategies, a better understanding of the processes underlying...
"Tendon disorders and injuries are one of the most common musculoskeletal disorders. Our knowledge of the causes and underlying mechanisms for the development of tendinopathies still remain fragmentary. Recent evidence has clearly implicated the presence of immune cells during early tendinopathy and we are beginning to better understand the origin and properties of these cells. Recently, we...
"Introduction
Tendon injuries occur commonly in human and equine athletes. Post-injury, the healing response is inadequate leading to increased deposition of scar-tissue and high re-injury rates. This has motivated the development of novel treatments which promote superior tissue regeneration. Particular interest has surrounded the use of bone-marrow mesenchymal stromal cells (BM-MSCs), with...
"Despite the high incidence of tendon injuries globally, an optimal treatment strategy has yet to be defined1. A key challenge for tendon repair is the alignment of the repaired matrix into orientations which provide maximal mechanical strength2, 3. Using oriented implants for tissue growth combined with either exogenous or endogenous stem cells may provide a solution. Previous research has...
"A well-balanced shift from pro- to anti-inflammatory processes during healing appears essential for successful regeneration and may prevent from chronic diseases or tissue damage. Resolution of inflammation is an active process, which is regulated by specialized pro-resolving mediators (SPMs) such as lipoxins, annexins, and resolvins. The contribution of these mediators to the severity of...
INTRODUCTION
Tendon tissues host different cell populations that play important roles in their physiology and pathophysiology. A hallmark of tendon injuries and diseases is the persistent inflammatory response that can self-amplify and lead to chronicity. The inflammatory phase of tendinopathy is characterized by increased vascularization and influx of immune cells (mast cells, macrophages, T...
