Conveners
S54+S14 Regulation of cell phenotype in osteochondral tissues: towards RNA therapy for bone and cartilage repair + Biological testing of 3D-printed biomaterials – towards updated norms
- Veronika Hruschka (Ludwig Boltzmann Institute for Traumatology )
- Marley Dewey (University of Pittsburgh )
- Andrea Lolli
- Eric Farrell (Department of Oral and Maxillofacial Surgery, Erasmus MC, University Medical Center Rotterdam )
- Carlos Julio Peniche Silva (cBITE, MERLN Institute, Maastricht University)
- Daniel Seitz (BioMed Center Innovation gGmbH)
"MicroRNAs, short non-coding RNAs, are important regulators of skeletal development. Several individual microRNAs have been shown to alter long bone growth with most interest focused on the cartilage ‘specific’ microRNA, miR-140. We made a new miR-140-null mouse and confirmed the skeletal phenotype, identifying a range of target genes that the microRNA controls. The null mice also have...
"Increasing attention is being paid to the use of RNA molecules as agents to facilitate tissue healing. Messenger RNAs (mRNAs) introduced into the cell induce synthesis of their encoded proteins. This approachholds several advantages over traditional DNA-based gene therapy including improved cell internalization and higher transfection efficiencies, without disruption of the host genome. In...
Background:
Cell adhesion can be guided through the mechanical signals provided by the biomaterials1,2. These signals are transmitted to the cytoskeleton, to the nuclei and finally to the chromatin3. The chromatin remodeling is highly dynamic and sensitive to these cues and imposes extensive effects on DNA-related metabolism, including transcription. Recently, chromatin has been identified as...
"It is well known that cartilage possesses a low intrinsic regenerative potential, causing tissue damage that remains unhealed and contributes to a high socioeconomical burden for affected patients. New strategies to restore the properties of load bearing, friction-reducing hyaline cartilage are thus timely. Tissue engineering and regenerative medicine approaches must deal with the high...
"Introduction
Silica based materials have been commonly studied in the field of bone regeneration, due to their bioactivity and osteogenic properties1. However, silica materials have low degradation rates and are brittle, which can be overcome by developing hybrid materials, which include an organic part bound to the silica network2. Despite these can be processed in several shapes, there is...
Tissue engineering as a field may benefit from progressively implementing and spreading the use of standards, conceived to support the repeatability, replicability and efficient comparing of research results among experts in the field worldwide. Considering that scaffolds play a fundamental role in many tissue engineering strategies, it would be interesting to count with an internationally...
