Conveners
S61 Tissue Engineering in Microgravity for Health in Space and on Earth
- Jeremy Teo (New York University Abu Dhabi )
- Cian O' Connor (Tissue Engineering Research Group, Department of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI))
Interest in manned spaceflights has increased in recent years and this brings about a surge in the need for more in-depth research into the adverse effects of spaceflights on the human body. In the absence of gravitational forces there are countless negative effects on the immune system. This dysfunction in the immune system can lead to increased susceptibility of infections by astronauts and...
"3D microenvironment maintains the transcriptome profile of T cells but not B cells in simulated microgravity
The adverse effects of space travel on the human body are abundant and with the rise in interest in manned spaceflight over recent years, there is an increased need for more research into these effects. In the absence of gravitational forces, one of the primary systems to be...
"Studies of cellular differentiation in simulated microgravity reveal an important role for β-actin in mechanosensing
Authors: Oscar Sapkota, Tomas Venit and Piergiorgio Percipalle
Science Division, Biology Program, New York University Abu Dhabi, Abu Dhabi, UAE
Introduction
Mechanotransduction is mediated by the actin cytoskeleton and it is important in helping stem cells determine their...
"Biotechnology engineering in a microgravity environment receives much attention these days. The absence of sedimentation enables scientists to combine any number of substances in an even mixture, prevent cell sedimentation, and enhance agglomeration into a natural 3D formation. Additional beneficial is the absence of hydrostatic pressure, permitting secondary forces like diffusion and surface...
"Research concerning 3D constructs of biological tissues has made enormous progress over the past twenty years. The ultimate aim is to create in vitro models that mimic, at least in part, morphology and function of biological tissues, leading to future applications ranging from clinical modeling to clinical transplants.
Despite the progress in obtaining various types of constructs (organoids...
"The space environment allows for research that simply cannot be done on Earth. It stimulates innovation, because terrestrial solutions may not work in space, but, at the same time, space-inspired solutions can be transferable to Earth.
The European Space Agency (ESA) is Europe’s gateway to space. Its mission is to shape the development of Europe’s space capability and to ensure that...
"Hydrogels are considered as very promising materials to be used as scaffolds in tissue engineering. Their relatively tunable mechanical properties make them particularly suitable for different tissues including vascular ones. It is well known that, during the regeneration phase, the mechanical properties of the scaffolds can play a relevant role in cellular growth and adhesion.
When...
