Conveners
S63 Towards automated technologies for organoid-based tissue biomanufacturing
- Ioannis Papantoniou
Biomanufacturing cells and tissues from human pluripotent stem cells (hPSCs) typically strives to guide differentiation through developmentally relevant pathways in a well-defined, dynamic bioreactor environment. While great strides have been made in differentiating hPSCs to many somatic cell types, robust biomanufacturing remains a roadblock to clinical progress of hPSC-derived cell and...
"Over 300 million cases of osteoarthritis were reported in 2017, stating one of the most prevalent chronic joint diseases worldwide characterized predominantly by long-term progressive cartilage and subchondral bone degeneration. Conventional therapy approaches utilize pharmacotherapy mostly for pain relief and at end stage disease treated by whole joint replacement surgery to retrieve some...
"Introduction: Progenitor cells from the periosteum are major contributors in fracture healing with contribution to the formation of the cartilaginous fracture callus. It was previously demonstrated that microspheroids of human periosteum derived cells, differentiated towards the chondrogenic lineage, could be assembled into scaffold-free constructs that healed murine critical-size long bone...
"INTRODUCTION:
In the field of bioprinting, which is growing very rapidly, the bioextrusion technology represents more than 80% of the market. The other technologies (e.g. microvalve or inkjet) are used for their ability to print droplets. Among them, laser-assisted bioprinting (LAB) represents the most advanced technology to achieve high resolution printing and high cell viability [1][2]....
"Introduction: For a viable and compliant clinical translation of tissue-engineered products, the adoption of automated technologies has been acknowledged as a prerequisite. Recently, the use of chondrogenic microtissue and organoid assemblies has shown promising results in long-bone defect regeneration through endochondral ossification[1]. Hence, automated biomanufacturing technologies able...
"Cartilage microtissues are promising tissue modules for bottom up biofabrication of implants leading to bone defect regeneration. Most of the protocols for the development of these cartilaginous microtissues have been carried out in static setups, however in order to further achieve higher scales suspension process needs to be investigated. In the present study we explored the impact of...
