"Introduction: Soft tissue-engineered constructs (sTECs) require tailored dynamic changes in their structure-properties-process (SPP) relations to preserve their functionality throughout the tissue regenerative process. At the initial stages of regeneration, a highly interconnected architecture is recommended to accelerate plaque adhesion and blood clot formation. At later stages of...
"Introduction: Soft tissue-engineered constructs (sTECs) require tailored dynamic changes in their structure-properties-process (SPP) relations to preserve their functionality throughout the tissue regenerative process. At the initial stages of regeneration, a highly interconnected architecture is recommended to accelerate plaque adhesion and blood clot formation. At later stages of...
Simultaneous flexibility, strength and toughness are exceptional characteristics of soft biological tissues which do not exist in man-made materials. Soft tissue-engineered meshes (sTEMs) should exhibit tissue-like mechanics and geometries for better performance and fit. However, the majority of current clinical meshes for soft tissue regeneration are conventional fabrics made by knitting or...
"During the last decade, bioprinting technology has gradually made tremendous progress in manufacturing complex cell-laden hydrogel-based constructs especially for advanced 3D in vitro models. However, most models still lack full complexity. The combination of multiple state-of-the-art printing processes is currently expected to make up for this shortcoming and to improve the outcome after...
"Introduction: Age-related macular degeneration (AMD) is a major cause of blindness worldwide, affecting 170 million people1. AMD consists in a degeneration of the central retina due to age-related changes in Bruch’s membrane (BM) and in the retinal pigment epithelium (RPE). Currently, periodic intravitreal injections of anti-vascular endothelial growth factor drugs are the gold standard...
Chronic kidney diseases (CKD) is the twelfth leading cause of death worldwide, where patients present a gradual loss/impairment in kidney function, leading to end-stage renal disease (ESD). People suffering from ESD have limited life-saving temporal renal replacements options, such as the kidney dialysis, while donor organ transplantation is still the current gold standard, generally hampered...
