INTRODUCTION: Type 1 diabetes is an autoimmune condition which through pathological immune system action mediates
β-cell destruction, reducing insulin production capacity1. A proposed replacement for insulin injections and pancreas transplants is the production of semi-artificial pancreas, which combines immunoisolative and oxygen permeable polymer hydrogels with mechanically resistant...
To meet the clinical need for small diameter vascular graft, we developed a new generation of human tissue-engineered vascular graft (TEVG) entirely made of biological material. Vessels were produced by weaving yarn of Cell-Assembled extracellular Matrix (CAM). Study objectives were: 1) to assess the graft behavior in the arterial circulation of immunosuppressed rats to evaluate its in vivo...
Microvasculature is essential for the exchange of gas and nutrient for most tissues in our body. Some tissue structures such as the meniscus presents spatially confined blood vessels adjacent to non-vascularized regions. In biofabrication, mimicking the spatial distribution of such vascular components is paramount, as capillary ingrowth into non-vascularized tissues can lead to tissue matrix...
Introduction: Cleft palate is a congenital condition affecting the development of maxillofacial bones. Current treatment is based on the surgical repair of the soft tissues in order to generate a physical barrier between the oral and nasal cavities. However, this treatment is associated with subsequent bone hypoplasia and misdevelopment in most patients. In this regard, we recently generated a...
Introduction:
Bladder cancer is the 10th most common cancer worldwide. About 20% of bladder cancers are muscle-invasive and are indication for a radical cystectomy. The use of ileal segment is a standard method for urinary diversion after bladder removal. Use of this method extend surgical procedure and lead to numerous metabolic complications. To overcome these side effects, tissue...
For almost a century, in vitro 3D tissue models of skin are known. However, these 3D skin models are mainly used for basic cosmetic testing rather than for clinical application. This is because of a lack of reproducible methodology, physiological structures and tissue architecture. An essential step in the development of a physiologically relevant in-vitro skin model is the incorporation of...
