Introduction
Tumor models have advanced over the years as scientists have made several improvements. In the past, typically 2D cultures were used. Due to their artificial nature, their results are often not transferable to the human pathophysiology. 3D models are a promising approach for a more in vivo-like microenvironment. Here, the upcoming field of biofabrication makes it possible to...
Introduction
Cycles of vascular growth and regression can be observed in physiology as well as pathology. Angiogenic phases are intermitted by vessel regression in the menstrual or hair cycle and tumor-supplying vasculature can regrow after therapeutic intervention through anti-angiogenic therapies (AATs)(1-3). While AATs based on limiting the availability of VEGF have been successfully used...
Introduction: Cancer is increasingly a global health issue. Each year, millions of people are diagnosed with cancer around the world and it is still a leading cause of death. Despite the significant improvement in treatment and prevention, there is a critical need for more effective strategies, like the use of synthetic or natural agents to inhibit, retard, or reverse the process of...
Introduction: Age-related macula degeneration (AMD) is a blinding neurodegenerative disease of the retina. It affects 4% of the population over 60. For over 90% of patients there is no cure due to cellular atrophy of the retina. Progressive deposit accumulation (drusen) under the retinal pigment epithelium (RPE) is the hallmark of the disease. Currently, no single (in vitro) model...
Tissue engineering strategies are widely used to model and study the bone marrow microenvironment in healthy and pathological conditions. Yet, while bone function highly depends on mechanical stimulation, the effects of biomechanical stimuli on the bone marrow niche, specifically on bone marrow adipose tissue (BMAT) is poorly understood due to a lack of representative in vitro loading models....
"Introduction: Cyclophilins are peptidyl-prolyl isomerases that regulate several biological processes. Importantly, cyclophilin-A promotes the remodelling of extracellular matrix (ECM) proteins by activating matrix metalloproteinases and is implicated in the correct folding of collagen fibres. Cyclophilin inhibition has shown beneficial therapeutic effects at various stages of liver disease,...
The emergence of human induced stem cells (hiPSCs) circumvents the ethical controversy of human embryonic pluripotent stem cells(hPSCs), introducing great feasibility in stem cell research. There are various methods to trigger the cellular reprogramming process, including viruses, plasmids, episomal plasmids, RNAs, proteins, and small molecules. mRNA-based reprogramming has up to 4% efficiency...
