Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022

Session

PS15 Biologically inspired and Engineered disease models

PS15

Not scheduled

ICE Krakow

336. A NEW PRINTABLE ALGINATE / HYALURONIC ACID / GELATIN HYDROGEL SUITABLE FOR BIOFABRICATION OF IN VITRO AND IN VIVO METASTATIC MELANOMA MODELS (1)

Schmid, Rafael (Laboratory for Tissue-Engineering and Regenerative Medicine, Department of Plastic and Hand Surgery, University Hospital of Erlangen )

poster

Introduction
Tumor models have advanced over the years as scientists have made several improvements. In the past, typically 2D cultures were used. Due to their artificial nature, their results are often not transferable to the human pathophysiology. 3D models are a promising approach for a more in vivo-like microenvironment. Here, the upcoming field of biofabrication makes it possible to...

815. AN IN VITRO MODEL TO STUDY THE RECOVERY OF THERAPEUTICALLY ABLATED VASCULAR NETWORKS

Krattiger, Lisa Amanda (University and University Hospital Zurich )

poster

Introduction
Cycles of vascular growth and regression can be observed in physiology as well as pathology. Angiogenic phases are intermitted by vessel regression in the menstrual or hair cycle and tumor-supplying vasculature can regrow after therapeutic intervention through anti-angiogenic therapies (AATs)(1-3). While AATs based on limiting the availability of VEGF have been successfully used...

813. Bio-waste natural bioactive compounds as a power tool in anticancer therapies

Bajek, Anna (Tissue Engineering Department Chair of Urology and Andrology, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun )

poster

Introduction: Cancer is increasingly a global health issue. Each year, millions of people are diagnosed with cancer around the world and it is still a leading cause of death. Despite the significant improvement in treatment and prevention, there is a critical need for more effective strategies, like the use of synthetic or natural agents to inhibit, retard, or reverse the process of...

814. DEPOSITS AND NEURO-DEGENERATIVE DISEASE: A 3D BIOPRINTED IN VITRO MODEL FOR AGE-RELATED MACULA DEGENERATION

Emri, Eszter (Department of Human Genetics, Amsterdam UMC; 3D-cellular Bioprinting Platform Amsterdam UMC, NL )

poster

Introduction: Age-related macula degeneration (AMD) is a blinding neurodegenerative disease of the retina. It affects 4% of the population over 60. For over 90% of patients there is no cure due to cellular atrophy of the retina. Progressive deposit accumulation (drusen) under the retinal pigment epithelium (RPE) is the hallmark of the disease. Currently, no single (in vitro) model...

800. DEVELOPMENT OF AN IN VITRO SYNTHETIC POLYMER-BASED 3D CONTRACTION MODEL FOR FIBROSIS

Kumari, Jyoti (Radboud University)

poster

"DEVELOPMENT OF AN IN VITRO SYNTHETIC POLYMER-BASED 3D CONTRACTION MODEL FOR FIBROSIS

J. Kumari1,2 M.Sc, F.A.D.T.G Wagener2 PhD, and P.Kouwer1 PhD

1 Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525 AJ, Nijmegen, The Netherlands, 2 Department of Dentistry, Section of Orthodontics and Craniofacial Biology, Radboud University Medical Centre, Nijmegen, The...

337. Engineering a 3D bone marrow adipose composite tissue loading model suitable for studying mechanobiological questions

Bock, Nathalie (Queensland University of Technology)

poster

Tissue engineering strategies are widely used to model and study the bone marrow microenvironment in healthy and pathological conditions. Yet, while bone function highly depends on mechanical stimulation, the effects of biomechanical stimuli on the bone marrow niche, specifically on bone marrow adipose tissue (BMAT) is poorly understood due to a lack of representative in vitro loading models....

799. Extracellular matrix remodeling upon cyclophilin inhibitor treatment in patient derived models of liver fibrosis and injury

Campinoti, Sara (Roger Williams Institute of Hepatology )

poster

"Introduction: Cyclophilins are peptidyl-prolyl isomerases that regulate several biological processes. Importantly, cyclophilin-A promotes the remodelling of extracellular matrix (ECM) proteins by activating matrix metalloproteinases and is implicated in the correct folding of collagen fibres. Cyclophilin inhibition has shown beneficial therapeutic effects at various stages of liver disease,...

1029. HIGH-EFFICIENCY MICROFLUIDICS-BASED MRNA REPROGRAMMING FACILITATES A LARGE COHORT OF PATIENT STUDIES

Qin, Wei (Department of Industrial Engineering, Università di Padova, Italy)

poster

The emergence of human induced stem cells (hiPSCs) circumvents the ethical controversy of human embryonic pluripotent stem cells(hPSCs), introducing great feasibility in stem cell research. There are various methods to trigger the cellular reprogramming process, including viruses, plasmids, episomal plasmids, RNAs, proteins, and small molecules. mRNA-based reprogramming has up to 4% efficiency...