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Cobzariu, Isabella (Grigore T. Popa University of Medicine and Pharmacy)poster
Introduction. In the recent years, three-dimensional (3D) bioprinted hydrogels has been developed and tested for regenerative medicine due to their ability to mimic the anatomical structures [1,2]. Various bioinks that contain polymeric biomaterials, especially natural polymers have been prepared and tested[3] due to their biocompatibility and favorable environment for cell attachment and...
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Alehosseini, Morteza (DTU )poster
Bone glues may be the greatest alternative for bonding fractured bone segments compared to metal implants, which require screws, makes the treatment longer, have more adverse-effects for large fracture fragments, and are not suitable for small fracture fragments. The main purpose of this research is to investigate whether a Conductive, Adhesive, Reconfigurable, and Elastomeric material (called...
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Millesi, Flavia (Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Vienna)poster
Introduction
Hydrogel fillings have been successful in enhancing artificial conduits for nerve injuries, but the ideal hydrogel is yet to be found. Its discovery is impeded by an overflow of available products as well as a lack of in vitro experiments that fully analyze the effects of these hydrogels on cells crucial for nerve regeneration.Methodology
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This study investigated various... -
Kłodzińska, Ewa (Department of Analytical Chemistry and Instrumental Analysis, Institute of Sport - National Research Institute, Warsaw, Poland. ALPINUS CHEMIA)poster
The recent emergence of nanotechnology has provided a new therapeutic modality in case of silver nanoparticles. Dressings containing silver form the basis for the treatment of burns and wounds, either acute or chronic ones. The aim of the study was to examine silver release from the different wound dressings: commercially available (Atrauman Ag, Aquacel Ag) and experimental (FKDP-AgNPs) using...
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Liu, Keng-fan (Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital)poster
A novel decellularized bone matrix was established by the supercritical carbon dioxide (SCCO2) extraction technology. The most commonly employed surgical technique is bone grafting, to enhance bone regeneration in orthopaedic surgery. The current study investigated the role of SCCO2 -decellularized bone matrix (scDBM) as bio-scaffold seeded with allogeneic adipose-derived mesenchymal stem...
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Tuszyńska, Marta (Faculty of Medicine, Department of Tissue Engineering, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun)poster
Introduction:Hydrogels are biomaterials that possess appropriate physicochemical and mechanical properties enabling the formation of a three-dimensional, stable structure used in tissue engineering, providing an environment conducive to the survival and proliferation of cells. The cytotoxicity test is performed to assess the overall toxicity of developed materials. Evaluation of the...
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Klak, Marta (Foundation of Research and Science Development )poster
*Purpose: Tissue engineering is an interdisciplinary field involving activities based on two interrelated areas: developing new methods to repair, regenerate and replace damaged tissues and organs. Currently, the most suitable materials for bioprinting of living constructs are biomaterials based on decellularized extracellular matrix (ECM). In this researches, we made two independent...
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Lesieur, Romane (BioTis (U1026))poster
Introduction
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In pathologies of esophagus the restoration of digestive continuity after the ablation of a portion of the organ is currently ensured by the interposition of a colon segment or by the tubulation of the stomach. The development of a tissue-engineered esophageal substitute is part of the improvement of the surgical treatment of esophageal pathologies. The first... -
Sanjairaj, Vijayavenkataraman (New York University Abu Dhabi )poster
Urochordates are the closest invertebrate relative to humans and commonly referred to as tunicates, a name ascribed to their leathery outer “tunic”. The tunic is the outer covering of the organism which functions as the exoskeleton and is rich in carbohydrates and proteins. Invasive or fouling tunicates pose a great threat to the indigenous marine ecosystem and governments spend several...
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Jeyakumar, Vivek (Universität fur weiterbildung Krems)poster
INTRODUCTION: Hypertrophic chondrocytes mediate the enduring pathway for endochondral bone formation. However, challenges in tissue-engineered bone constructs include functionality under the mechanical environment inside in vivo conditions. We aim to fabricate a mechanically stable Silk fibroin (SF) carrier incorporating decellularized cartilage derived extracellular matrix (CD-ECM) and...
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Ziai, Yasamin (IPPT PAN )poster
Biomolecule sensing is one of the most fascinating areas in the application of smart biopolymers. One of the most explored areas is the design of soft nanomaterials for glucose monitoring, which is of great significance in the diabetic therapeutic market. Multifunctional biomimetic, biocompatible, and smart materials based on hydrogels with physical properties similar to living tissues are of...
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Zarei, Moein (Department of Polymer and Biomaterials Science, West Pomeranian University of Technology in Szczecin )poster
Introduction: The main aim of tissue engineering is to design biological substitutes in order to enhance and restore damaged tissues or organs, and biomaterials for fabricating the scaffolds play a crucial role. Collagen (COL), the main part of the ECM and a group of structural proteins which contributes to the extracellular scaffolding, was considered for scaffolds preparation. Studies have...
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Sasimonthon, Witchayut (Department of Materials Science and Engineering and Insigneo institute for in silico medicine, University of Sheffield )poster
Introduction
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Craniofacial bone defects can be caused from birth defect anomalies and road traffic accidents and affect vital functions such as chewing, swallowing, speaking, and breathing1. Autografts are the current gold standard for treating these defects but suffer from limited tissue available for harvest, long operation times, and donor site morbidity. Tissue-engineering has been known... -
Norbertczak, Halina T. (School of Biomedical Sciences, Faculty of Biological Sciences, and Institute of Medical and Biological Engineering, School of Mechanical Engineering, Faculty of Engineering and Physical Sciences )poster
Introduction
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Osteoarthritis (OA) of articular cartilage is a progressive and debilitating disease, often necessitating a total joint replacement. Between 2005 and 2015 the worldwide prevalence of OA increased by 32.9 % (from 17.9 to 23.7 million cases) [1]. There is therefore a demand for early stage interventions to stave off or delay replacement surgery. A potential treatment is a... -
Ruiz-Alonso, Sandra (University of the Basque Country UPV/EHU )poster
Tissue engineering has undergone a great revolution in terms of the strategies, technologies and materials it uses (1). In this way, much more complex approximations have been proposed achieving a notorious improvement of the treatment of injuries as frequent as tendinopathies. In this sense, 3D bioprinting could help for the development of scaffolds whose biological or mechanical...
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Jacobs, Mira (Department of Obstetrics, University and University Hospital of Zurich )poster
Introduction
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A major drawback of most chemo- and radiotherapeutic cancer treatments is their toxicity to the ovaries, meaning they may affect fertility and/or endocrine function of female patients. The state-of-the-art method nowadays is the cryopreservation of the ovaries. However, with transplantation of ovarian tissue after the end of cancer treatment there is always the risk to also... -
Woods, Ian (Tissue Engineering Research Group, Dept. of Anatomy & Regenerative Medicine, Royal College of Surgeons in Ireland (RCSI))poster
The injured spinal cord (SC) generates a unique and complex pathophysiology which presents a multifaceted challenge for repair. Broadly, normally supportive astroglia become reactive following injury and form a glial scar. This scar in turn inhibits recovery by releasing an impenetrable inhibitive extracellular matrix (ECM), which prevents axonal regrowth. Tissue engineering approaches aim to...
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Olszewska, Alicja (Faculty of Materials Science and Engineering, Warsaw University of Technology)poster
Introduction:
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Breast cancer is the most frequent cancer among women. New therapeutic approaches need to be introduced to develop an effective cancer therapy, which could inhibit, or reverse cancer spread to distant locations. The most prevalent cancer treatment method is resection, during which the tumor with the adjacent tissue (margin) is removed. In such case, patient-tailored hydrogel... -
Fekner, Zuzanna ( Department of Regenerative Medicine, Cell and Tissue Bank, Chair of Urology and Andrology, Ludwik Rydygier Medical College, Nicolaus Copernicus University in Torun )poster
Introduction: Urinary bladder regeneration using tissue engineering is one of the major challenges of reconstructive urology. Commonly used urinary bladder reconstruction techniques that utilize gastrointestinal tissues, are associated with many complications. One of the most promising alternative seems to be the use of bladder acellular matrix (BAM). The use of BAM in clinical practice...
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Cheng, Wei-jie (School of Pharmacy, Taipei Medical University )poster
In this study, we utilized the decellularized extracellular matrix (ECM) under the ultrasonication to obtain the ultrasonic decellularized ECM (UdECM). In SDS-PAGE studies, the results demonstrated that UdECM was mainly composed of type I collagen. The mechanical strength increased with the increase of concentration of UdECM in rheology studies. In addition, the scanning electron microscope...
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Saiani, Alberto (Department of Materials, University of Manchester )poster
INTRODUCTION: Liver diseases are becoming a significant public medical burden[1]. To overcome the lack of donor livers and high cost of therapy, this project aims to exploit a long-term culture system that maintains hepatocyte specific functions [2] and cell viability for liver regeneration using self-assembled peptide hydrogels to mimic the normal hepatic extracellular matrix (ECM). Previous...
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Alkildani, Said (BerlinAnayltix GmbH )poster
(1) Background: The aim of the present study was the biocompatibility analysis of a novel xenogeneic vascular graft material (PAP) based on native collagen won from porcine aorta using the subcutaneous implantation model up to 120 days post implantationem. As a control, an already commercially available collagen-based vessel graft (XenoSure®) based on bovine pericardium was used. Another focus...
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Moon, Jungwoo (Asan Medical Center )poster
Introduction: Excessive muscle damage does not regenerate on its own, so research is being conducted to regenerate the muscle in tissue engineering. In this study, myoblast-patch that mimics muscle fiber was generated and characterized in vitro test.
Method: To generate myoblast-patch, scaffolds were fabricated with biocompatible materials using electrospinning. Two groups of scaffolds were...
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Tran, Thi Nga (Faculty of Science and Engineering, Bernal Institute, University of Limerick )poster
Biocomposites made of poly(propylene carbonate) (PPC), a carbon dioxide (CO2) derived polymer, and a renewable polysaccharide are promising materials for several applications such as biomaterials and packaging. However, most of PPC-based biocomposites exhibit low mechanical and optical properties due to the inherent incompatibility between PPC and most other polymers. In this work, a novel...
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Sánchez-Porras, David (Tissue Engineering Group, Department of Histology, University of Granada and Instituto de Investigación Biosanitaria ibs.GRANADA, Spain)poster
Introduction: Damage of the sclerocorneal limbus may lead to limbal stem cell deficiency (LSCD), loss of corneal transparency, and blindness. Keratoplasty is the standard treatment for corneal transplantation disorders, but it is contraindicated in cases with LSCD or limbal damage1, which are very difficult to manage. Generation of a biological substitute of the sclerocorneal limbus could...
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Chiu, Hsin-cheng (National Tsing Hua University )poster
Although oral formulations of anticancer chemotherapies are clinically available, the therapeutic action relies on drug absorption, being inevitably accompanied with systemic side effects. It is thus desirable to develop oral therapy systems for the local treatment of colon cancers featured with highly selective delivery and minimized systemic drug absorption. The present study demonstrates...
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Gruppuso, Martina (University of Trieste )poster
Introduction: Electrospun wound dressings are emerging as promising candidates in the field of wound care since they present a similar architecture to natural extracellular matrix (ECM). Their composition can include both synthetic and natural polymers, the latter enabling a biological other than structural mimicking of ECM. Due to the high surface-to-volume ratio, electrospun matrices can...
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Salagierski, Szymon (Department of Glass Technology and Amorphous Coatings, Faculty of Materials Science and Ceramics, AGH University of Science and Technology)poster
Hydrogel materials are widely used in medicine and tissue engineering due to their similarity to the natural tissues of the human body. They are well known for their high biocompatibility and swelling - the ability to absorb large amounts of water. These properties determine the possibility of the use of hydrogels in the regeneration of cartilage tissue. In order to enhance regeneration...
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Geevarghese, Rency (Silesian University of Technology)poster
Title: HYDROGELS FOR 3D EXTRUSION PRINTING OF GRADIENT SCAFFOLDS
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Rency Geevarghese1, Joanna Żur-Pińska1, Małgorzata Włodarczyk-Biegun1,2 *
1Biofabrication and Bio-Instructive Materials, Biotechnology Center, The Silesian University of Technology, B. Krzywoustego 8, 44-100 Gliwice, Poland.
2Polymer Science, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747... -
Kamakura, Shinji (Tohoku University )poster
Introduction: Even though conventionally prepared octacalcium phosphate and collagen composite (OCPcol) has exhibited excellent bone regeneration with angiogenesis (1, 2) and has already been commercialized for treating bone defects (3), reproducible appositional bone formation with OCPcol has never been achieved. Recently, it was developed double concentration of OCP/Col with applying liquid...
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Markovic, Marica (3D Printing and Biofabrication Group, TU Wien, Austrian Cluster for Tissue Regeneration, Vienna, Austria )poster
The use of xeno-free (animal origin-free) hydrogels to support the growth of cells significantly increased in the recent years. The advantage of these materials in comparison with animal derivates is the reproducibility of structural, mechanical and biological properties and, additionally, overcoming of potential immunological complications and disease transmission in vivo. Many novel...
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Massaro, Maria Stefania (Biomedical Center, Faculty of Medicine in Pilsen, Charles University )poster
Introduction: In the last two decades research has been focused on the development of biologically-derived matrices for reconstructive medicine[1]. Decellularized tissues from a xenogeneic donor represent a growth-friendly environment for cells of different species, including human, lacking most of the immunogenic components[2]. Decellularized porcine liver resembles the human counterpart and...
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Thanarak, Jeerawan (The University of Sheffield)poster
Natural scaffolds derived from living tissue have been used in clinical applications. They provide similar architecture and composition to the target tissue and can be remodelled as desired. However, they still have some drawbacks as there is a risk of disease transmission and may require additional surgery. Therefore, extracellular matrix (ECM) based biohybrid scaffolds have been developed...
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Chen, Meng-yen (Division of Oral and Maxillofacial Surgery)poster
Supercritical CO2 (SCCO2) technology was used to eliminate the cells, fat and non-collagenous materials while preserving a native collagen scaffold as a biomedical device for bone defects. We used porcine matrix bones with 3D CAD/CAM carving to reconstruct a personalized, wide range and complex-shaped bone. In oral cancer patients upto 30–50% of need mandibulectomy and autologous fibula...
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Khanmohammadi, Mehdi (Iran University of Medical Sciences )poster
We proposed a new formation for fibrous mat fabrication from derivatives of polyvinyl alcohol (PVA) and gelatin (Gela) through horseradish peroxidase mediated crosslinking which provides sustain release of methylprednisolone (MP) as a therapeutic approach for SCI regeneration. The polymeric solution of PVA and Gela conjugated with phenolic moieties (PVAPh & GelaPh respectively) containing...
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Hruschka, Veronika (Ludwig Boltzmann Institute for Traumatology )poster
Introduction: Mesenchymal stromal cells (MSCs) have the potential to respond to injury and aid in repair and regeneration of damaged tissues. Bone marrow and adipose tissue are the major sources of MSCs for clinical applications. Previous studies in animal models suggested that the regenerative activity of aged stem cells/MSCs can be enhanced by exposure to biomimetic microenvironments. The...
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Gasperini, Luca (3B's )poster
Introduction: Extracellular matrix (ECM)-based bioinks have been steadily gaining interest in the field of bioprinting to develop biologically relevant and functional tissue constructs. To mimic the complexity of structures and compositions that characterize a tissue’s own ECM, several ECM-extraction methodologies have been used. However, their outcomes seldomly reflect what is found in native...
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Jung, Shannon Anna ( Institute for Technical and Macromolecular Chemistry, DWI - Leibniz Institute for Interactive Materials )poster
Heart valve diseases have become one of the main causes for mortality worldwide. To increase the life expectancy of these patients, surgical replacements using mechanical or biological heart valve implants are most commonly used. However, mechanical implants entail the lifelong intake of anticoagulation medication and biological implants exhibit a limited lifetime of 10-20 years. In addition,...
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Kuniaková, Marcela (Comenius University )poster
Introduction: Several scaffolds have been introduced for urethral tissue engineering. However, acellular human urethral scaffold harvested from deceased donors may provide significant advantages in comparison to synthetic, composite or other biological scaffolds. The aim of this study was to develop a protocol for decellularization of human urethra that preserves substantial components of...
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