INTRODUCTION
Ameloblastoma (AM) is a benign, epithelial tumour of the jawbones originating from the residual epithelium of the tooth germ. AM shows a locally aggressive behaviour characterised by progressive bone resorption. The precise molecular mechanisms behind the disruption of bone homeostasis are unclear. We developed a novel 3D model composed of an AM tumour mass and a bone stroma to...
INTRODUCTION
Cancers are one of the leading causes of death worldwide. Failure to obtain effective treatment could be attributed to the irrelevancy of commonly utilized two-dimensional (2D) in vitro and animal models in drug evaluation. Three-dimensional (3D) in vitro models aim to provide more resemblance to in vivo cancer cell microenvironment and therefore represent promising tools for...
Introduction
Hematopoietic stem cell and progenitor cell (HSPC) niches are provided by the bone marrow (BM) tissue, from where HSPCs ensure the blood cells production throughout individual’s life. In contrast to the murine counterparts, human HSPC niches remain poorly understood due to accessibility and ethical difficulties. In order to bypass these limitations, our lab has engineered...
