Introduction: The use of nerve autografts remains as the gold standard method for critical nerve repair. However, due to their well-known disadvantage new nerve grafts are still needed. In this sense, decellularized peripheral nerve-derived extracellular matrices (ECMs) have emerged as a promising alternative, but these processes may affect the structure, composition and biomechanical...
Introduction: As a reliable alternative to autografts, decellularized peripheral nerve allografts (DPNAs) maintain the complex natural structure of native nerves minimizing the immune response. However, there is currently a lack of decellularization methods for peripheral nerve that remove cells minimizing any adverse effect in extracellular matrix (ECM) that overcoming the autograft results....
Introduction:
The surgical repair of nerve transection injuries remains a challenging task and often results in unsatisfactory functional recovery. If a direct coaptation is not possible, the current gold-standard is the use of an autograft. However, the availability of autologous nerve tissue is limited and the harvest of a donor nerve entails functional loss and possible donor site...
