Introduction: The term “extracellular vesicle” (EV) is broadly used to describe naturally released cellular vesicles with a lipid bilayer and without a nucleus. EV represent a heterogeneous population that is generally categorized into subpopulations based on characteristics such as size, biogenesis, function, and composition. The field of extracellular vesicle (EV) research is growing...
Introduction: Since the cardiac tissue possesses limited regenerative capacity, cardiovascular diseases still remain one of the most common causes of death worldwide and their currently existing treatment approaches, including cell-based therapies, are still unsatisfactory. Thus, new therapeutic strategies need to be developed, which is a one of the challenges of modern biomedical sciences....
Injuries to peripheral nerves is a common health problem, often resulting in sensory and motor dysfunction in respective parts of the body. One of the most important facilitators of the regeneration process are Schwann cells (SCs), which basement membrane is chiefly comprised of laminin. Extracellular vesicles (EVs) are considered playing an important role in the intercellular communication...
Introduction: Development of bioartificial substitutes of the human oral mucosa and palate is strictly dependent on the availability of human keratinocyte cells cultured from small tissue biopsies1. Although cell culture methods have been improved over the last years, epithelial cells typically show low proliferation rates and cell culture protocols should be improved for an efficient use in...
Introduction: Vitamin C (ascorbic acid) is a potent antioxidant and a crucial co-factor of many enzymes, including Fe2+ and alpha-ketoglutarate dependent dioxygenases such as TET (ten-eleven-translocation) proteins involved in active DNA demethylation. TET enzymes (TET1, TET2 and TET3) are able to oxidize 5-methylcytosine to 5-hydroxymethylcytosine and subsequently to 5-formylcytosine and...
