Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022

Session

PS34 Advanced therapy approaches in tissue engineering

PS34

Not scheduled

ICE Krakow

490. INNERVATION IN BONE TISSUE HEALED WITH CHEMICALLY MODIFIED RNA

Polain, Claire (MERLN institute )

poster

Introduction: The formation and outgrowth of nerve fibers during fracture healing is a highly important process. These nerve fibers are distributed throughout the entirety of skeletal tissue, being crucial for sensing and responding to stimuli such as mechanical load. Bone morphogenic proteins (BMPs) are commonly used for bone tissue regeneration, due to their osteogenic character. However,...

489. NON-VIRAL GENE THERAPY FOR RECESSIVE DYSTROPHIC EPIDERMOLYSIS BULLOSA: HYPER BRANCHED AMINATED POLYESTERS MEDIATED MINICIRCLE DNA DELIVERY

Wang, Xianqing (University College Dublin )

poster

Introduction: Recessive dystrophic epidermolysis bullosa (RDEB) is a rare autosomal inherited skin blistering disorder caused by mutations in the type VII collagen gene (COL7A1). The large size of COL7A1 is a big delivery challenge for both viral and non-viral vectors and seriously hindered the development of therapeutic gene replacement therapy for RDEB. Our group has developed a series of...