INTRODUCTION: Many human disorders display unknown tissues relationships affecting disease progression and drugs response (1). While in vitro assays fail in recapitulating organ-organ connection, animal models reveal species-specific drug outcomes. To this purpose, a novel multi-organ microphysiological system (MIVO®) has been adopted to fluidically connect 3D ovarian cancer tissues with a...
Introduction
Stem cell-based therapies are considered one of the most promising disciplines in the field
of biomedicine. Bladder cancer patients could benefit from such therapies directed to promote healing after invasive surgeries or to lessen urinary incontinence, a common side effect of both cancer itself and the treatment. One particularly attractive source of cells for bladder...
INTRODUCTION
Advances in organoid research has led to the development of retinal organoids capable of forming optic cups as well as giving rise to all major cell types of the neuroretina, most notably mature photoreceptors. These retinal organoids can be used for studying retinal development or to serve as a source of photoreceptors for transplantation therapy. However, several challenges...
INTRODUCTION
Despite big efforts and capital invested, drug commercialization is severely hampered by high attrition rates impacting all development phases. Cardiac-side effects are the fourth cause of post-marketing drug withdrawal and stand behind almost 30% during the pre-marketing phase. With the blame on current testing systems, the generation of affordable and more representative...
