"A new Gellan Gum/Lignin bioink: a promising route for cartilage repair
Maria A. Bonifacioa,, Stefania Cometab, Andrea Cochisc, Annachiara Scalzoned, Piergiorgio Gentiled, Alessandro C. Scaliac, Lia Rimondinic, Piero Mastrorillie, Elvira De Giglioa
aDepartment of Chemistry, University of Bari, Via Orabona 4, 70126 Bari, Italy
bJaber Innovation s.r.l., Via Calcutta 8, 00144 Rome,...
Introduction
Peripheral nerve injuries (PNIs) less than 5 mm in length self-repair compared with those with wider gaps1,2. Traditionally, PNIs of 20 mm or less have been repaired either by suturing nerves end-to-end, or by grafting. However, these techniques present surgical and patient recovery drawbacks, prompting the search for better technologies. Nerve guidance conduits (NGCs) have shown...
Introduction
Regeneration of cartilage tissue is a difficult and lengthy process. An active fibrous substrate that mimics the random arrangement of fibres in the extracellular matrix (ECM) may be a promising strategy to aid the self-repair process. Fibrils form interconnected, three-dimensional network whose morphology promotes oxygen and nutrient delivery to cells. Tuning the surface...
Introduction
Human tissues are structurally and compositionally heterogeneous, often consisting of gradients in architecture, extracellular matrix constituents, cell phenotypes, and biochemical factors. Mimicking the structural complexity through scaffold designs for in-vitro tissue regeneration is challenging and yet to be achieved. Melt Electrowriting (MEW) is a high-resolution additive...
Introduction: The reconstruction of the abdominal wall after abdominal surgery [NN1] results in the loss of tissue biomechanical properties and the occurrence of surgical site infections (SSI). Current available solutions (i.e. implantation of surgical meshes) can restore the abdominal tissue wall biomechanics although inducing significant clinical complications. Bioengineered spider silk...
Hydrogels derived from extracellular matrices (ECM-gels) have been described with promising features to promote tissue regeneration, since they preserve several components of native tissues. However, their weak mechanical properties impair ECM-gels use in load-bearing applications. Previously, we have shown that the incorporation of oxidized forms of graphene, one of the strongest materials in...
Alginate, a natural linear polysaccharide polymer, extracted from brown seaweed, is extensively applied due to its biocompatibility, all- aqueous ease of handling and relatively low costs. Alginate easily forms a hydrogel when crosslinked with a bivalent ion, as calcium. However, Alginate hydrogel holds low mechanical properties and it is cell-inert. To overcome these drawbacks and to improve...
Introduction:
The pain and gradually progressing limitation of mobility are the main burdens of osteoarthritis (OA). Each year, an increasing number of people are affected by the OA. Meanwhile, despite the efforts of many scientific groups, the successful regeneration of cartilage tissue remains an unresolved issue. Amongst many therapeutic strategies, those involving hydrogels are one of the...
In vitro models of biological barriers (e.g., lung epithelium, intestinal epithelium) provide an important benchmark for studying the physiopathological processes (e.g., nutrient and metabolite exchange, interactions with external virus or bacteria) involved in the development of several diseases (e.g., respiratory tract infections, carcinomas). These models represent a reliable platform for a...
