Stress urinary incontinence is the most common type of urinary incontinence. Actual standard therapeutic modalitie offer symptomatic relief without treating the underlying disorder. Therefore, we developed a novel technology to apply cells for recovery of the urethral sphincter by waterjet (WJ). Based on our previous study in cadaveric samples1, we investigated if a) porcine muscle−derived...
Computer modelling is applied to a wide range of engineering applications to predict the outcome of a physical system. In bioengineering, additive manufacturing (AM) technologies and computer modelling can be placed side by side to fabricate tissue engineering (TE) scaffolds and to study their behaviour under certain circumstances (e.g., the effect of shape, size, and porosity on mechanical...
Introduction: Emerging as one of the major causes of disability and death, respiratory diseases affect millions of people worldwide.
To date, despite numerous efforts and clinical attempts, there are no effective treatments to repair long-segment defects, and a standard procedure is still missing.
Among the ventured clinical applications, Tissue Engineering (TE) approaches hold the potential...
In skin research, 2D monolayer in vitro models provide only limited fields of application as they do not sufficiently mimic physiological properties. Since in the spirit of 3R’s (Replacement, Reduction, and Refinement) animal models are to be avoided, new approaches like 3D skin equivalents (SE) are needed to close the in vitro/in vivo gap. Cell culture inserts to produce SE are commercially...
Interleukin 7 (IL-7) is an immune cytokine that plays a critical role in the maturation and homeostasis of T and B-lymphocytes. The absence of IL-7 significantly affects the proliferation of early lymphoid progenitor cells and leads to the development of severe combined immunodeficiency syndrome. To date, there are active studies of recombinant IL-7 as a means of restoring the immune system of...
