The biomedical sector is experiencing a technological transformation in its attempt to solve current and next future global health issues. The scarcity of organ donors in a growing elderly population accentuates the need to generate new strategies based on the use of cutting-edge technologies for regenerative medicine.
In recent years, the emergence of 3D bioprinting has allowed great...
Introduction
Around 10% of long bone fractures display inadequate bone regeneration, leading to delayed- or non-unions. Amino acids have shown to play important roles in bone regeneration. In particular, citrulline has revealed itself as an enhancer of bone regeneration in murine bone defect healing models. Oral citrulline supplementation stimulated callus formation and lead to a balanced...
Introduction:
Diseases of the periodontium start in general with the recession of the periodontal ligament (PDL) and leads to loosening of the tooth within the alveolar bone. The cementum and periodontal ligament play important roles in physiological tooth function. Therefore, cementum and periodontal ligament regeneration are critical for periodontal regenerative therapy. Decades of clinical...
Introduction:
The human bone marrow (BM) is home to Hematopoietic Stem Cells (HSCs) and Bone Marrow Stromal Cells (hBMSCs) which are known to contain skeletal stem cell populations. Whereas the HSC compartment is well characterized, the identity and function of the hBMSC populations remain obscure and requires thorough investigation. A better understanding of the BM and the accommodated cells...
Bone is constantly exposed to a range of macro-scale loading which creates a complex mechanical microenvironment for its resident cells. One such mechanical stress generated is hydrostatic pressure (HP) which plays an important role in cell function and fate determination. Although HP is a constant mechanical cue for bone resident cells, little is known about the effect of this external...
