"Introduction
Everyday thousands of people of all ages across the world are admitted to hospitals because of the severe injuries or malfunction of some vital organs [1]. Organ or tissue transplantation is a standard therapy to treat these patients. Irony of fact that many of these people will die due to the paucity of donor organs and high processing cost involved in organ transplantation...
Articular cartilage has a poor capacity for self-repair, consequently, defects are one of the major causes of immobility and poor quality of life for millions of individuals worldwide. Damage to articular cartilage can be caused by trauma, ageing, genetic factors and degenerative diseases such as osteoarthritis and is often irreversible without surgical intervention. The current clinically...
Introduction: In the last decade, the interest in understanding perinatal tissues, including the human umbilical cord, have exponentially increased due to the plasticity, differentiation, and immune modulatory properties of these tissues1,2. Advances in the comprehension of the biology of human umbilical cord and their cells, will contribute to establish their potential use in tissue...
Introduction: Cell culturing of human cells used in oral mucosa and cornea tissue engineering can be optimized by using three-dimensional cell culture platforms1. In general, these systems comprise an extracellular matrix where cells can be cultured in a 3D spatial microenvironment able to simulate the physiological conditions in which cells are found in vivo, including cell-cell and...
INTRODUCTION
Mesenchymal stem cells have contributed to the continuous progress of tissue engineering and regenerative medicine. Among different mesenchymal stem origins, the ones derived from adipose tissue possess many advantages including the ease of tissue harvesting, self-renewal potential and rapid population doubling time. Adipose derived stem cells (ADSC) have multipotent ability and...
INTRODUCTION: There is a growing interest in biomimetic materials which are capable of recapitulating the native extra-cellular environment and drive/guide cell behaviour. Hyaluronan (HA) and fibrin (FB) are two natural extracellular components that each play a pivotal role in modulating cellular behaviour, such as proliferation, migration and differentiation. Cells are capable of sensing...
