"An emerging feature of mechanical stimulation tissue engineering are flexible bioreactors that can move together with the actuation system. These have the potential of applying more physiologically relevant movement regimes than conventional systems. The development of such a bioreactor requires the optimal design and operational parameters. A mathematical model was developed to provide...
"Introduction
The medical device sector relies on the detail-oriented and often cutting-edge research of fundamental scientists. This type of research requires public funding to survive. As such, engaging effectively and meaningfully with the public in the research undertaken, for people to understand and appreciate the importance of funding lab-based, discovery research is vital for...
"Introduction. In the context of tissue engineering for regenerative medicine, the electrospinning technique consolidated itself as a valuable approach to fabricate tailored scaffolds. While its versatility lies in the possibility of controlling the process parameters, ambient parameters, and the properties related to the solvent system, the choice of the polymeric component itself results...
"Introduction
Restoring the normal structure and function of injured tendons is a major challenge in orthopaedics. The discovery of tendon-derived stem cells (TDSCs) provides a novel perspective to treat tendon injuries, which is expected to be an efficient approach to promote tendon repair and regeneration (Li et al., 2021).
Methodology
Isolation of TDSCs
The isolation of tendon derived...
"Introduction:
Tissue engineering has the purpose to find a resolutive treatment for unsolved pathologies, as tendon disorders, taking advantage of cell-free approaches [1]. Since tendinopathies have been related to persisting inflammation state, the application of immune regenerative strategies is getting attention by exploiting the immunomodulatory potential of stem cells and their...
"Introduction: Musculoskeletal diseases include more than 150 pathologies and have been reported to affect 1.71 billion people worldwide (1). Among the different conditions described, the number of cases of chronic tendinopathy and tendon/ligament injuries has reportedly increased, mainly due to the rise of life expectancy in many countries (2). The currently used therapeutic tools mainly...
Introduction:
Gelatin is a biocompatible polymer derived from natural sources. Its low cost and non toxicity make it an attractive alternative in tissue engineered scaffolds. Chitosan, a biodegradable polymer obtained from chitin, is widely used due to its antimicrobial properties and chemical similarity to glycosaminoglycans (GAGs) found in native tissue. Cellulose nanocrystals (CNCs) are 10...
"Introduction:
Stem cells-based therapy has emerged as a new strategy within the field of regenerative medicine, proving its effectiveness in tendon regeneration [1]. Amongst the stem cell sources, Adipose-Derived Stem Cells (ADSCs) can differentiate towards the tenogenic lineage and modulate the inflammatory environment [2]. However, the mechanisms through which ADSCs promote tendon healing...
INTRODUCTION
Tendinopathy (also called tendinitis or tendinosis) is a tendon disorder resulting from repetitive motion in the affected area or during athletic activity.It is related to pain and swelling in the affected area, with decreasing mechanical strength and movement. [1] With the rapid growth of an aging population, there is an increasing incidence of chronic tendinopathy.Current...
"Introduction:
Recovery after tendon injuries remains a challenge for the orthopaedics to be solved due to the frequently poor clinical outcomes (1,2). To date, the cellular implications as well as the structural changes in tendinopathy are not fully known, especially concerning the link between inflammation and the early stages of tendinopathy (3). The aim of this research was to assess the...
Introduction: As a tissue engineering approach, synthetic and natural polymer composites are explored to create tissue scaffolds that provide requirements such as biocompatibility, biomimetic interface, mechanical properties close to native tissue, and promotion of cell attachment and differentiation. Blends of natural and synthetic electrospun fibers can provide excellent combinations to...
