Introduction: Tendon injuries represent a significant personal and socioeconomical burden whose medical treatments remain insufficient to restore normal functionality. Tendon healing is often impaired, contributing for the lesion severity, risk of re-ruptures and ultimately tendon dysfunction[1]. Persistent inflammatory cues have been associated to the development of tendon pathologies, and to...
Multipotent mesenchymal stromal cells (MSC) represent a promising therapeutic tool for tendon regeneration. They are capable of tenogenic differentiation, which is one of the mechanisms contributing to the regenerative effect of MSC after transplantation into tendon lesions and is furthermore required for tissue engineering approaches. Tenogenic differentiation is most typically induced by...
Chronic rotator cuff tears (RCTs) are one of the most common injuries of shoulder pain. Despite the recent advances in surgical techniques and improved clinical outcomes of arthroscopically repaired rotator cuffs (RCs), complete functional recovery—without retear—of the RC tendon through tendon-to-bone interface (TBI) regeneration remains a key clinical goal to be achieved. Inspired by the...
