"Recent works on dynamic hydrogels, using non-covalent and/or dynamic covalent linkages, have shown that dynamic and spatial-temporal complex materials are promising step-towards the recapitulation of extracellular matrix (ECM) functionality and structure 1-5. However, the uncontrollable network properties across timescales make these dynamic hydrogels insufficient for fully recapitulating the...
Combining upconversion nanoparticles (UCNPs) and UV-sensitive polymers to form a drug delivery system (DDS) is a promising strategy to circumvent drawbacks of direct UV excitation in clinical applications. This study tuned up core-shell UCNPs with shell thickness of 6 nm and emission wavelength falling in the ultraviolet region at 350 nm under near-infrared (NIR) light irradiation at 980 nm....
"Introduction
Nowadays, soft tissue damage are typically replaced by grafts from other body parts. However, tissue grafting can be problematic due to the need for several surgical procedures or lack of sufficient tissue material. Recently, hydrogels have emerge as an alternative treatment for tissue regeneration. Specifically guanosine-based hydrogels show unique self-assembly properties...
"Introduction
Organoids have the potential to revolutionise drug discovery and development, providing an in vitro platform to determine drug efficacy and toxicity while reducing the need for animal testing. However, the wider adoption of organoids is held back by reliance on animal derived matrices for the production and culture of organoids. Animal derived materials are not only unethical...
"Introduction
As one of the most outstanding technology, cardiac patches hold the potential to restore cardiac function clinically. Many biomaterials used to fabricate cardiac patches have emerged during the last decade. Synthetic polymers can be tailored on a molecular level to fit any requirement that should be met to function as an integral part of a beating heart.
A facile method was...
Introduction
3D cell culture is an increasingly reliable method to mimic the in vivo environment in vitro and offers a robust platform for several investigations ranging from disease modelling, regenerative medicine to drug discovery and development. In addition, having more physiologically relevant 3D models of both healthy and diseased tissues will allow the better understanding of the...
