Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022

Session

PS67 We’ve got your back: the challenges and success of advanced regenerative treatments for intervertebral disc regeneration

PS67

Not scheduled

ICE Krakow

775. 3D Bioprinting Whole Intervertebral Discs To Inform Regenerative Therapies

Kibble, Matthew (University of Manchester)

poster

"INTRODUCTION: Back pain is one of the leading causes of disability, with an estimated 540 million sufferers worldwide. Degeneration of the intervertebral discs (IVDs) is implicated in 40% of cases; however, treatment remains limited and regenerative therapies are becoming essential. 3D bioprinting provides a powerful tool to create biomimetic tissue analogues with properties closely matched...

768. Assessing the clinical relevance of pre-clinical models through investigating their nutrient microenvironment and regeneration capacity

Mc Donnell, Emily (Trinity College Dublin)

poster

"Despite exciting advances in regenerative medicine, cell-based strategies for treating degenerative disc disease remain in their infancy. After demonstrating safety and efficacy in animal studies, many of these therapies enter a critical period between preclinical validation and clinical evaluation, where they do not appear to work to the same extent in humans. It is commonly believed that...

773. BIOPRINTED INTERVERTEBRAL DISC: IN VITRO EVALUATION OF A COLLAGEN/HYALURONIC ACID BIOINK WITH OVINE DISC CELLS

Le Visage, Catherine (Inserm Regenerative Medicine and Skeleton)

poster

"Introduction. Intervertebral disc (IVD) degeneration is one of the main cause of low back pain (LBP), affecting over 600 million individuals worldwide. Mechanisms associated with the degeneration remain poorly characterized, in part due to the lack of adequate IVD models. Reproducing in vitro the complex structure of an IVD, with its gelatinous core Nucleus Pulposus (NP) surrounded by the...

765. Characterization of molecular mechanisms regulating plasticity of human nasal chondrocytes to improve tissue regeneration

Apte, Janhavi (University of Basel)

poster

"Introduction: Intervertebral disc (IVD) disease is a common condition characterized by degeneration of one or more discs that separate the vertebrae causing back and neck pain. Current treatments focus entirely on symptom management rather than causal cure. This research focuses on using nasal chondrocytes (NCs) to ameliorate degenerative disc disease (DDD). NCs originate from multipotent...

770. HYPEROSMOLAR EXPANSION MEDIUM IMPROVES CANINE NUCLEUS PULPOSUS CELL PHENOTYPE

Laagland, Lisanne (Utrecht University)

poster

"Lower back pain due to intervertebral disc (IVD) degeneration is a major health problem and often starts in the centre of the IVD, called the nucleus pulposus (NP). NP cells are considered potential candidates for cell-based therapies to induce regeneration of the IVD. However, as the availability of NP cells is limited, extensive in vitro expansion is needed prior to transplantation which...

778. SELF-ASSEMBLING PEPTIDE HYDROGELS FOR NUCLEUS AUGMENTATION OF THE INTERVERTEBRAL DISC

Culbert, Matthew (University of Leeds)

poster

"INTRODUCTION
Lower back pain affects 80 % of adults and has estimated costs up to 1 – 2 % of GDP1,2. Current surgical treatments include spinal fusion, but outcomes are poor with reoperation required in 20% of patients3. An emerging and more regenerative approach is nucleus augmentation, which aims to restore healthy disc anatomy and biomechanical function through the delivery of a...