"The dopaminergic system is vital for the control of both motor control (nigrostriatal pathway, A9 dopaminergic neurons), and reward (mesocorticolimbic pathway, A10 dopaminergic neurons). Both pathways are associated with different types of diseases: the nigrostriatal pathway is most commonly associated with Parkinson’s disease, whereas the mesocorticolimbic pathway becomes dysregulated in...
"Introduction
Huntington’s disease (HD) is a progressive neurodegenerative disorder with autosomal-dominant heritability characterized by the aggregation of mutant huntingtin (mHTT) protein. HD is described by the region-specific neuronal degeneration of medium spiny neurons (MSNs) in the striatum, elevated Ca2+ signaling, and dendritic spine pathology. However, the pathway connecting...
"Introduction: The brain organoids derived from human-induced Pluripotent Stem Cells (iPSC) provide a tool to model and study human brain development and its pathology. Up to date reports regarding the role of mitochondrial biogenesis (MB) in cell-type specification during in vitro human cortical development are not available. By inducing mitochondrial biogenesis at different developmental...
