Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Conference 2022

Session

S10-2 Biofabricated Tissues and Organs for Clinical Impact

S10-2

Jun 30, 2022, 11:00 AM

ICE Krakow

Conveners

S10-2 Biofabricated Tissues and Organs for Clinical Impact

• Laura De Laporte
• Priscilla Briquez (Pritzker School of Molecular Engineering, University of Chicago)

114. Weaving a compliant Tissue-Engineered Vascular Graft from Cell-Assembled extracellular Matrix yarn

Roudier, Gaëtan (BioTis - Inserm U1026 )

6/30/22, 11:00 AM

podium presentation

Introduction: Vascular grafts are implanted daily, whether it is as leg or coronary bypasses or as arteriovenous shunts. Autologous blood vessels are the gold standard but have limited availability while synthetic materials are prone to thrombosis, intimal hyperplasia and infections. To overcome these limitations, our team produced a biological Tissue-Engineered Vascular Graft (TEVG) woven...

123. Exploring shape versatility on all-aqueous processing for cell encapsulation

Oliveira, Mariana B. (CICECO - Aveiro Institute of Materials. University of Aveiro )

6/30/22, 11:10 AM

podium presentation

Cell encapsulation in biomaterial microcompartments is a useful tool to deliver protected cell cargo into defective tissues. However, the processing of micrometric structures is often dependent on the use of typical emulsion agents, including oils and organic solvents. Those are often related with poor cell viability, or require complicated washing procedures to retrieve oil-free cell-laden...

124. Microfluidic production of immunoprotective enzymatically crosslinked polyethylene glycol-tyramine microgels for beta-cell replacement therapies

Araújo-Gomes, Nuno (Leijten Laboratory, Department of Developmental BioEngineering, TechMed Centre, University of Twente, Enschede, The Netherlands )

6/30/22, 11:20 AM

podium presentation

INTRODUCTION:
Transplantation of non-autologous β-cells is currently regarded as a promising therapy for the treatment of type 1 diabetes, caused by massive β-cell destruction, consequently resulting in insulin shortage. To evade the host’s immune responses, new materials are being developed to encapsulate and shield implanted β-cells. Several immunoprotective material formulations have been...

115. Tissue Engineered Graft from human Adipose-derived Stem Cells for Phalanx Construction in Children with Symbrachydactyly

Moya, Adrien (Department of Plastic, Reconstructive, Aesthetic, and Hand Surgery, University Hospital Basel, Basel, Switzerland )

6/30/22, 11:30 AM

podium presentation

Symbrachydactyly is a rare congenital upper limb anomaly, that occurs in 1/30,000- 1/40,000 live births resulting in children born with short boneless fingers. Nowadays, these pediatric patients are treated with phalangeal bone transfer from the foot. However, morbidities are occurring at the donor site which result in unstable toes with significant disfigurations that worsen with the child...

120. An innovative in vitro gut-on-a-chip model to investigate intestinal microbiota impact on brain functionality

Donnaloja, Francesca (Politecnico di Milano )

6/30/22, 11:40 AM

podium presentation

INTRODUCTION
The role of gut microbiota in neurodegeneration is becoming a very interesting topic nowadays, and innovative in vitro and in vivo tools are becoming increasingly a need to help in dissecting the biochemical pathways involved in microbiota-brain interaction. An innovative engineered multiorgan-on-a-chip platform able not only to mimic microbiota-gut-brain connection but also to...

116. Axially vascularized mandibular regeneration, a journey of thousand miles to improve patients’ smiles

Eweida, Ahmad (University of Alexandria, University of Heidelberg )

6/30/22, 11:50 AM

podium presentation

Introduction:
Axial vascularisation of tissue constructs is essential to maintain an adequate blood supply for a stable regeneration of clinically relevant 3D tissues. In the last 10 years, our research group has been investigating the efficacy of the arterio-venous loop (AV loop) as a model of axial vascularisation. The versatility of the AV loop could be demonstrated in various small and...

117. Engineering the Bioartificial Filtration Unit in a Kidney using Polyhydroxyalkanoates

Syed Mohamed, Syed Mohammad Daniel (University of Sheffield )

6/30/22, 12:00 PM

podium presentation

Introduction
Kidney failure happens due to two conditions; acute kidney injury (AKI) and chronic kidney disease (CKD). These lead to the deterioration of the glomerulus, the filtering unit in the kidney, leading ultimately to end-stage renal failure (ESRF). [1] Current treatments for ESRF, haemodialysis and kidney transplantation are inadequate since haemodialysis replaces filtration but not...

273. TOWARDS THE DEVELOPMENT OF A GELMA-BASED ORGANOTYPIC HUMAN SKIN MODEL USING A CUSTOM-MADE BIOREACTOR

Eltayari, Zahara (ICVS/3B’s )

6/30/22, 12:10 PM

podium presentation

"INTRODUCTION: Collagen I has been the gold standard material to generate many in vitro tissue models, including organotypic skin [1]. The rate of collagen remodeling by fibroblasts incorporated in the dermal part of the model, leads to significant dimensional changes during its development, which can be associated to additional hurdles when cultured within dynamic culture systems. These ones,...

859. Laser-based subtractive manufacturing for tissue engineering

Cruz-Moreira, Daniela (3B’s Research Group, I3BS – Research Institute on Biomaterials, Biodegradables and Biomimetics, ICVS/3B’s - PT Government Associate Laboratory, University of Minho)

6/30/22, 12:20 PM

podium presentation

"Introduction
linical translation of tissue engineering-based therapies is currently limited by the difficulty in inducing essential vascularisation for tissue viability after transplantation. Thick and metabolically demanding engineered tissues require a defined microvascular network to provide sufficient nutrient and gas exchange. Laser ablation has emerged as a promising technology to...