Conveners
S43-2 Multifunctional biomaterials supporting bone regeneration
- Elลผbieta Pamuลa (AGH University of Science and Technology)
- Timothy Douglas (Lancaster University )
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Man, Kenny (University of Birmingham)6/29/22, 1:30โฏPMpodium presentation
"Extracellular vesicles (EVs) have garnered growing attention as promising acellular tools for bone repair. Epigenetic regulation through histone deacetylase (HDAC) inhibition has been shown to increase differentiation capacity. Although EVs efficacy has been shown, their short half-life in vivo hinders their therapeutic potency. Gelatin methacryloyl (GelMA) hydrogels functionalised with...
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Schoffit, Sarah (Ecole Nationale Vรฉtรฉrinaire dโAlfort (Universitรฉ Paris-Est), 7 avenue du gรฉnรฉral de Gaulle, 94704 Maisons-Alfort Cedex, France and Laboratoire de Biologie, Bioingรฉnierie et Bioimagerie Ostรฉeo-Articulaire (B3OAโUMR CNRS 7052) Universitรฉ Paris Diderot, 10 A )6/29/22, 1:40โฏPMpodium presentation
"Introduction: Large bone defects are a challenge for orthopedic surgeons. BMPs are the most potent bone inductors and accelerators of bone growth. However, poor BMP-2 retention by scaffolds leads to its rapid clearance from implantation sites,1 and thus, require the use of supra-physiological doses. Serious concerns regarding BMP-2-related adverse effects have been reported (including...
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Gamna, Francesca (Politecnico di Torino )6/29/22, 1:50โฏPMpodium presentation
"Introduction: Several molecules of natural origin are of great interest to add specific surface functionalities to implant biomaterials: phenolic compounds and keratin can be used for different targets, as an example. They are derived from industrial processing of respectively plants or animals derivatives through a valorization process of waste and a sustainable circular economy approach....
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Briquez, Priscilla (Pritzker School of Molecular Engineering, University of Chicago)6/29/22, 2:00โฏPMpodium presentation
"Introduction
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The bone morphogenetic protein-2 (BMP-2) is one of the most potent growth factors for bone repair. In the clinic, BMP-2 is widely used for spinal fusion, particularly in the product called InFUSE Bone Graftยฎ (Medtronic). Despite its strong efficacy, the safety of BMP-2 remains questionable as some treated patients suffer from serious side-effects, such as ectopic bone formation,... -
Leemhuis, Hans (Matricel GmbH)6/29/22, 2:10โฏPMpodium presentation
"Collagen scaffolds are well known for their regenerative potential. However, the relatively poor mechanical properties represent a problem (scaffold deformation, partial collapse of internal open pore structure) for the translation into a clinical setting. In this study, we present a novel approach: A Mechano-Hybrid-Scaffold (MHS) that combines a collagen-based biomaterial with highly aligned...
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Alipour Ghassabi, Ata (Faculty of Engineering and Natural Sciences, Mechatronics Engineering, Sabanci University )6/29/22, 2:20โฏPMpodium presentation
"From a mechanical point of view, bone demonstrates exceptional mechanical properties owing to its complex hierarchical composite structure. The human skeleton acts as a support for the whole body as it withstands stresses produced by daily routines and gravitational force. As a result of these stresses, the bone regulates its geometry and density through activating formation and resorption...
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238. EFFECT OF 3D SCAFFOLD MORPHOLOGY ON BONE TISSUE REGENERATION BASED ON A MULTI-PHYSICS FEM MODELOzturk, Sezen (Faculty of Engineering and Natural Sciences, Materials Science and Nano Engineering, Sabanci University )6/29/22, 2:30โฏPMpodium presentation
Design and fabrication of optimal scaffolds for bone tissue repair is a multi-physics problem targeting osteoconductive, biodegradable material designs with loading of necessary growth factors. Therefore optimal tissue regeneration based on accurate analysis models including the degradation behavior of biomaterials is a critical design requirement (Byrne et al., 2007). In order to explore bone...
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Phelipe Hatt, Luan (AO Research Institute)6/29/22, 2:40โฏPMpodium presentation
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3D-printed personalised scaffolds are an attractive approach for mandibular bone repair. Poor mechanical stability of medical grade ceramics is a disadvantage. Also, delivery and retention of regenerative cells within 3D-printed scaffolds remains a challenge. This work aims to create 3D-printed personalised scaffolds based on a novel combination of materials with enhanced mechanical and... -
Van der Heide, Daphne (AO Research Institute Davos)6/29/22, 2:50โฏPMpodium presentation
"Introduction
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Most bone defects heal successfully, however, there is an increasing number of cases where bone self-healing is insufficient. Thus, there is a high need for scaffolds able to replace the clinical gold standard treatment autologous bone grafting, which entails donor site morbidity and lacks control over spatial architecture to match defect sites. Biofabrication offers great...