GAMM2025

Session

PP04: Robust coupling of continuum-biomechanical in silico models to establish active biological system models for later use in clinical applications – Co-design of modeling, numerics and usability

PP04

8 Apr 2025, 14:00

Lecture and Conference Centre

Conveners

PP04: Robust coupling of continuum-biomechanical in silico models to establish active biological system models for later use in clinical applications – Co-design of modeling, numerics and usability: PP04.01

• Tim Ricken

737. From Injury to Full Recovery: Monitoring Patient Progress Through Advanced Sensor and Motion Capture Technology

Annchristin Andres

08/04/2025, 14:00

Background: Advanced sensor insoles and motion capture technology can significantly enhance the monitoring of patient's rehabilitation progress with distal tibial fractures [1], [2]. This study utilizes the potential of these innovative tools to provide a more comprehensive assessment of a patient's gait and weight-bearing capacity following surgical intervention, offering a possibility for...

738. Investigation of the influence of screw position and screw insertion on the local micro-mechanics of the fracture gap and the interfragmentary movement

Michael Roland

08/04/2025, 14:20

Background: Femoral fractures are common injuries in orthopaedic trauma surgery that usually require surgical intervention with internal fixation devices such as intramedullary nails or implants. In the implant case studied here, the number of screws, their positioning and the corresponding angle of insertion can significantly influence the mechanical environment at the fracture site, which in...

739. Cell seeding dynamics in a porous scaffold material with applied sensitivity analysis

Henry Jäger

08/04/2025, 14:40

In this presentation, we report about ongoing work on in silico research for the better understanding of an experimental study for meniscus regeneration. In essence, this experiment uses a nonwoven scaffold that is colonized by chondrocytes and human mesenchymal stem cells. The mathematical description involves active processes at the cell level, as well as macroscopic effects. The...

740. Flexible macro-micro coupling for liver applications

Steffen Gerhäusser, Benjamin Uekermann

08/04/2025, 15:00

Simulation-based, patient-specific risk assessment via a digital liver twin has enormous potential in clinical applications such as personalized drug dosing or evaluation of the status and impairment of liver grafts before transplantation [1]. We present a flexible software framework for coupling tissue-scale and cellular-scale processes using FEniCS [2], libRoadRunner [3], and preCICE [4]....

741. Enriched and Discontinuous Galerkin Discretizations for a Cardiac Mechanics Benchmark Problem

Laura Stengel

08/04/2025, 15:20

Computer models of the human heart can lead to a better understanding of cardiac function. Since the objective of many of these models is to be used in a clinical setting, a compromise between computational cost and numerical accuracy is needed. Due to the high mathematical complexity of the underlying model, the finite element discretization commonly used may not be the optimal balance...

742. Advancing Endovascular Treatment: Simulating Thrombus Formation in Patient-Specific Aneurysms

Fabian Holzberger

08/04/2025, 15:40

Cerebral aneurysms (CAs), saccular dilations in the cerebral arteries affecting 3.2\% of the world's population, are a leading cause of stroke. Prone to rupture, they often cause subarachnoid bleeding, resulting in high mortality and severe disability. Endovascular coiling, a minimally invasive procedure, prevents rupture by altering blood flow and triggering clot formation within the...