Speaker
Description
The engineering of hierarchical tissues with controlled cellular behavior is essential for replicating the complexity and functionality of natural organs. In our approach, we employed nanoengineered scaffolds to creat hybrid bioink or controlled macromolecule assembly in pre-crosslinked bioinks (yet not chemically crosslinked) to guide (stem) cell migration and promote anisotropic cellular behavior, resulting in tissues with both structural integrity and key functional properties such as mechanical strength and nutrient flow. Furthermore, we optimized the maturation microenvironment to enhance the regeneration of complex tissue types, including skeletal muscle, nerve, and vascular networks. This work helps bridge the gap between bioengineered tissues and natural organs, advancing biofabrication techniques for more effective organ engineering and regenerative medicine applications.
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