Speaker
Description
Bone tissue engineering aims to develop biomaterials that can effectively repair and regenerate damaged bone tissue. Polycaprolactone and calcium phosphate, which are used in this field, are among the most widely used biocompatible materials. However, these materials lack antimicrobial properties and are vulnerable to bacterial adhesion and biofilm formation, which can lead to implant failure. To solve this problem, a strategy to improve antimicrobial properties while maintaining existing cell behavior properties is needed. In this study, the antimicrobial properties of scaffolds were improved through two chemical/mechanical antimicrobial strategies. For chemical antimicrobial properties, ZnO was coated on the scaffold surface with thicknesses of 10, 100, and 200 nm, and cell behavior and antimicrobial properties were evaluated. Scaffolds coated with 100 and 200 nm thick ZnO showed high antimicrobial properties against Escherichia coli (E. coli), and considering mechanical properties and cell activity, a 100 nm thick ZnO coating was appropriate. In addition, when calcium phosphate is synthesized in the form of nanostructures on the surface of the scaffold, it sterilizes bacteria (E. coli, Bacillus subtilis (B. subtilis)) mechanically attached to the surface and improves the proliferation and differentiation of bone cells. This antibacterial strategy of the scaffold is a groundbreaking strategy that can impart antibacterial properties while maintaining the cell behavior, shape, and characteristics of the existing scaffold.
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