Speaker
Description
Bone defects in the oral and maxillofacial region, often resulting from trauma, congenital anomalies, degenerative conditions, or therapeutic procedures, present significant clinical challenges. Guided bone regeneration (GBR) and guided tissue regeneration (GTR) are widely adopted strategies that rely on barrier membranes to spatially direct tissue growth. However, conventional collagen-based membranes frequently lack mechanical integrity, especially in complex or load-bearing defect geometries, while non-resorbable alternatives require secondary surgical removal.
In this work, we present a biofabricated, volume-stable, and fully biodegradable membrane engineered for alveolar ridge regeneration. The membrane is produced via electrospinning of polylactic acid (PLA), functionalised with osteoinductive nanoparticles and bone morphogenetic protein-2 (BMP-2). This approach ensures both mechanical resilience and biological activity, supporting localized, staged regeneration of hard and soft tissues. The nanofibrous architecture enables defect-specific conformability, while the embedded bioactive components facilitate cellular recruitment and differentiation.
This novel membrane design addresses critical limitations of current GBR/GTR technologies by combining structural stability with tailored biodegradation and regenerative potential. The platform holds strong translational promise for advanced dental tissue engineering and clinical bone repair.
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